踝关节腔内注射富含血小板血浆治疗慢性踝关节骨性关节炎的疗效及安全性分析  

Therapeutic Effectiveness and Safety of Platelet⁃rich Plasma Injection on Chronic Ankle Osteoarthritis

作　　者：魏芳远[1] 曲峰 张明珠 WEI Fang-yuan;QU Feng;ZHANG Ming-zhu(Foot and Ankle Surgery Center,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院足踝外科中心,北京100730

出　　处：《骨科》2022年第3期233-236,共4页ORTHOPAEDICS

摘　　要：目的探讨踝关节腔内注射富含血小板血浆(platelet⁃rich plasma,PRP)治疗慢性踝关节骨性关节炎的疗效及安全性。方法选取2018年1月至2020年3月于本院治疗的43例慢性踝关节骨性关节炎病人纳入本研究。病人采集自体静脉血制备PRP,均匀注入4 mL PRP至患踝关节。所有病人在首次注射后6周接受第二次注射,共给药两次。观察病人两次注射药物后的不良反应,记录病人治疗前后的疼痛视觉模拟量表(visual analogue scale,VAS)、美国足踝外科医师协会(American Orthopaedic Foot and Ankle Society,AOFAS)踝与后足功能评分系统、足踝能力评分(foot and ankle ability measure,FAAM),评价病人足踝部疼痛及功能改善情况。结果与治疗前相比,病人治疗3个月、6个月、9个月后的VAS评分均明显下降(P<0.05);治疗3个月、6个月后的FAAM评分和AOFAS评分均明显上升(P<0.05),治疗后9个月与治疗前比较,差异无统计学意义(P>0.05)。注射PRP后病人未出现严重不良反应。结论踝关节腔内两次注射PRP,6个月内可有效缓解慢性踝关节炎病人疼痛及运动功能,但是9个月时效果减退,整个治疗过程安全,无严重不良反应。Objective To investigate the efficacy and safety of platelet-rich plasma(PRP) injection in the treatment of chronic ankle osteoarthritis. Methods A total of 43 patients with chronic ankle osteoarthritis treated in our hospital from January 2018 to March 2020 were selected. Autologous venous blood was extracted from each patient to prepare PRP. Patients received two injections of PRP(4 mL) into the symptomatic ankles at an interval of 6 weeks. Adverse reactions after injection were recorded, and ankle pain and functional improvement were evaluated by visual analogue scale(VAS), American Orthopaedic Foot and Ankle Society(AOFAS) ankle hindfoot scale, foot and ankle ability measure(FAAM). Results Compared with pretreatment,VAS scores of the patients were significantly decreased at 3rd, 6th and 9th months after treatment(P<0.05).FAAM scores and AOFAS ankle hindfoot scores were significantly increased(P<0.05) at 3rd and 6th months after treatment. However, there was no significant difference before and 9 months after treatment(P>0.05). No serious adverse reactions occurred after PRP injection. Conclusion Injections of PRP(4 mL) at an interval of6 weeks are safe and effective treatments for chronic ankle osteoarthritis, which can effectively improve the patients’ foot pain and movement limitation.

关 键 词：富含血小板血浆 踝关节腔内注射 慢性踝关节骨性关节炎 

分 类 号：R684.3[医药卫生—骨科学]