健康体检人群中混合性阴道炎与宫颈人乳头瘤病毒感染的相关性研究  

Correlation Between Mixed Vaginitis and Cervical Human Papillomavirus Infection in Healthy People

作　　者：刘婷婷[1,2] 易念华 付晴晴[2] 曾雪慧[2] LIU Tingting;YI Nianhua;FU Qingqing;ZENG Xuehui(Department of Women′s Health Care,Maternal and Child Health Hosiptal of Hubei Province,Wuhan Hubei 430071,China)

机构地区：[1]武汉科技大学职业危害识别与控制湖北省重点实验室,湖北武汉430071 [2]湖北省妇幼保健院妇女保健科

出　　处：《华南国防医学杂志》2022年第4期257-260,共4页Military Medical Journal of South China

基　　金：湖北省卫生健康科研基金资助(WJ2019H161)。

摘　　要：目的了解阴道微生态与宫颈人乳头瘤病毒(human papillomavirus,HPV)感染的相关性。方法选取2020-06/2020-12月在某三甲妇幼保健机构健康中心行常规妇科体检的680名妇女,均行阴道微生态、宫颈HPV检测。根据HPV感染情况分为HPV阳性组(n=121),HPV阴性组(n=559)。结果HPV阳性组16、18型高危阳性有33人(27.27%),非16、18型的高危阳性有75人(61.98%),仅低危HPV感染的有13人(10.74%)。HPV阳性组51例(42.15%)合并多重HPV感染。本研究中人群阴道微生态失衡的有342例(50.19%),其中细菌性阴道炎(bacterialvag-initis,BV)最为常见,其次为外阴阴道假丝酵母菌病(vulvovaginal candidiasis,VVC),其中混合性阴道炎、pH值与HPV感染差异具有统计学意义(P<0.05)。Logistic回归分析显示混合性阴道炎是HPV感染的独立危险因素(OR=2.479,95%CI:1.403~4.382)。结论临床上针对HPV感染,应采用改善阴道微环境,维持正常菌群的方案。治疗混合性阴道炎,对于降低HPV感染率,提高HPV的清除率起着重要的作用。Objective To investigate the correlation between vaginal microecology and cervical human papillomavirus(HPV)infection.Methods A total of 680 women who underwent gynecological physical examination in a level 3 maternal and child health care institution were selected from June to December 2020,and they were tested in vaginal microecology and cervical HPV.According to condition of HPV infection,the patients were divided into HPV positive group(n=121)and HPV negative group(n=559).Results In HPV positive group,33 cases(27.27%)were high-risk positive of 16 and 18 types,75 cases(61.98%)were high-risk positive for non 16 and 18 type,and 13 cases(10.74%)were low-risk HPV infection.51 cases(42.15%)in HPV positive group complicated with multiple HPV infection.There were 342 cases(50.19%)of vaginal microecological imbalance,which bacterial vaginitis(BV)was the most common,the second was vulvovaginal candidiasis(VVC).There was statistical significance between mixed infection,pH and HPV infection(P<0.05).Logistic regression showed that mixed vaginitis was an independent risk factor for HPV infection(OR=2.479,95%CI:1.403-4.382).Conclusion It is necessary to improve vaginal microenvironment,maintain normal flora.Treatment of mixed infections plays an important role in reducing HPV infection and improving HPV clearance.

关 键 词：混合性阴道炎 人乳头瘤病毒 妇科体检 

分 类 号：R711[医药卫生—妇产科学]