中药复方治疗脓毒症伴急性胃肠损伤用药规律的数据挖掘研究  

Study on the Traditional Chinese Medicine Compound Prescription Rules for Sepsis with Acute Gastrointestinal Injury Based on Data Mining

作　　者：陈敏[1] 凌琪华[1] 王倩[1] Chen Min;Ling Qihua;Wang Qian(Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院,上海201203

出　　处：《中国中医急症》2022年第5期758-762,共5页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82074156);上海市“科技创新行动计划”医学创新研究专项项目(20Y21900300,21Y11920500)。

摘　　要：目的基于数据挖掘技术探讨中药复方治疗脓毒症伴急性胃肠损伤(AGI)处方的用药配伍规律,为临床治疗组方选择提供参考。方法筛选中国知网、维普、万方、中国生物医学文献服务系统、PubMed、Web of Science中收录的2000年1月至2021年4月发表的临床研究中医药治疗脓毒症AGI的处方,并运用SPSS Statistics26.0对纳入的中药处方进行分析。结果筛选出55篇合格的文献,收录病例3386人,涉及中药处方55首,中药103味。单味中药使用频率前3位为大黄(37次,7.44%)、甘草(32次,6.44%)、茯苓(21次,4.23%)。药物功效以补虚类(120次,25.64%)、清热类(75次,16.03%)、泻下类(50次,10.68%)最常用。中药药性以寒(172次,34.75%)、温(157次,31.72%)、平(96次,19.39%)为主,药味以苦(276次,39.04%)、甘(216次,30.55%)、辛(148次,20.93%)为主,归经以脾(342次,15.95%)、胃(290次,13.53%)、肺(221次,10.31%)为主。系统聚类分析可得到5个有效聚类群,高频药物关联规则分析得出27条药对及药组,其中大黄-甘草支持度最高。结论脓毒症伴AGI具有热结、血瘀、脾虚的特点,以泻热通腑、益气健脾为主要治法。Objective:To analyze the prescription rules of traditional Chinese medicine compound in the treatment of sepsis with acute gastrointestinal injury based on data mining,and to provide reference for the selection of clinical drug prescription.Methods:The prescriptions for treating sepsis with acute gastrointestinal injury were retrieved from databases such as PubMed,Web of Science,CNKI,Wanfang,VIP,and CBM from January 2000 to April 2021.Data analysis was conducted on the prescription rules of traditional Chinese medicine by SPSS 26.0.Results:A total of 55 eligible literature,with 3386 patients enrolled,55 effective traditional Chinese medicine prescriptions and 103 kinds of herbs were included.Rhubarb(37 times,7.44%),licorice(32 times,6.44%)and poria cocos(21 times,4.23%)were the top three in frequency of traditional Chinese medicine.The top three in efficacy were tonic class(120 times,25.64%),heat class(75 times,16.03%),diarrhea class(50 times,10.68%).The top three proportions in property in Chinese medicine were cold(172 times,34.75%),warm(157 times,31.72%)and mild(96 times,19.39%).The top three proportions in flavor of Chinese medicine were bitter(276 times,39.04%),sweet(216 times,30.55%),and acrid(148 times,20.93%).The highest proportion of meridian of Chinese medicine was the spleen(342 times,15.95%),followed by the stomach(290 times,13.53%)and lung(221times,10.31%).The clustering icicle graph could be divided into 5 effective clustering groups,and the association rule analysis resulted in 27 medicine pairs and groups,with rhubarb-licorice having the highest support.Conclusion:Sepsis with acute gastrointestinal injury has the characteristics of heat knot,blood stasis and spleen deficiency,and the main principles of treatment are purging heat and purging viscera,benefiting qi and strengthening spleen.

关 键 词：脓毒症 急性胃肠损伤 中药复方 用药规律 数据挖掘 

分 类 号：R631[医药卫生—外科学]