基于GSK-3β信号通路防治骨质疏松的天然产物作用研究进展  

Development of natural products in prevention and treatment of osteoporosis based on GSK-3β signaling pathway

作　　者：钟燕婷 杨亚军 李嘉晓 廖红波 崔燎 ZHONG Yan-ting;YANG Ya-jun;LI Jia-xiao;LIAO Hong-bo;CUI Liao(Dept of Pharmacology,School of Pharmacy,Guangdong Medical University,Zhanjiang Guangdong 524023,China;Guangdong Key Lab for Research and Development of Nature Drugs,Guangdong Medical University,Zhanjiang Guangdong 524023,China;South China University of Technology,Guangzhou 510110,China)

机构地区：[1]广东医科大学药学院药理学教研室,广东湛江524023 [2]广东医科大学广东天然药物研究与开发重点实验室,广东湛江524023 [3]华南理工大学医学院,广东广州510110

出　　处：《中国药理学通报》2022年第6期817-821,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81273518);广东省科技计划项目(No 2020B1515120052)。

摘　　要：糖原合酶激酶-3β(glycogen synthase kinase-3β,GSK-3β)异常会引起骨代谢紊乱,导致骨质疏松,其特征是骨量丢失和骨微结构破坏,往往会增加骨折发生率。来源于植物的天然产物可以作为预防和治疗骨质疏松的潜在药物。该文综述了GSK-3β通路和骨代谢的密切联系,并阐述了黄酮类、异黄酮类、多糖和皂苷类、酚类、生物碱类、胺的衍生物类等天然产物调控GSK-3β信号通路防治骨质疏松的研究进展,为进一步开发可能有效防治骨质疏松的药物提供科学依据。Abnormality of glycogen synthase kinase-3β(GSK-3β)triggers a deleterious consequence of disorder of bone metabolism,contributing to osteoporosis.Osteoporosis is characterized by bone loss and destruction of bone microstructure,which often leads to the increase of incidence rate of fracture.Natural products derived from plants can be used as potential drugs to prevent and treat osteoporosis.In this review,we elaborates on the intimate connection between GSK-3βand bone metabolism,and summarizes natural products of flavonoids,isoflavones,polysaccharides and saponins,phenols,alkaloids and amine derivatives regulating GSK-3βpathway in the prevention and treatment of osteoporosis,which may provide scientific evidence for further development of drugs that may effectively prevent and treat osteoporosis.

关 键 词：植物 天然产物 GSK-3Β 骨代谢 骨质疏松 机制 

分 类 号：R282.71[医药卫生—中药学] R336[医药卫生—中医学]