大花美人蕉根中1个新的对映-贝壳杉烷型二萜类化合物  

A new ent-kauranoid from rhizomes of Canna generalis

作　　者：周文婷 龚志伟 ZHOU Wen-ting;GONG Zhi-wei(School of Chemistry and Chemical Engineering,Wuhan University of Science and Technology,Wuhan 430081,China)

机构地区：[1]武汉科技大学化学与化工学院,湖北武汉430081

出　　处：《药学学报》2022年第5期1440-1443,共4页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金项目(51608400);煤转化与新型炭材料湖北省重点实验室开放基金项目(WKDM202108)。

摘　　要：采用硅胶柱色谱、高效液相色谱等方法对大花美人蕉根的乙醇提取物中的化学成分进行分离纯化,并运用现代波谱学手段鉴定化合物结构。从中分离得到2个对映-贝壳杉烷型二萜类化合物,鉴定为(5R,8S,9S,10R,13R)-2-酮-对映-贝壳杉-15-烯-17-酸(1)和(4R,5S,8S,9S,10S,13R)-19-羟基-对映-贝壳杉-15-烯-17-酸(2),化合物1为新化合物,化合物2为首次从大花美人蕉根中分离得到。Two ent-kauranoids were isolated from the ethanol extraction of rhizomes of Canna generalis(Cannaceae),and were purified by various technologies,including silica gel and high performance liquid chromatography,and their structures were determined by modern spectroscopy techniques as(5R,8S,9S,10R,13R)-2-oxoent-kaur-15-en-17-oic acid(1)and(4R,5S,8S,9S,10S,13R)-19-hydroxy-ent-kaur-15-en-17-oic acid(2).Compound1 is a new ent-kauranoid,and compound 2 is obtained from rhizomes of Canna generalis for the first time.

关 键 词：大花美人蕉 根 对映-贝壳杉烷型二萜 分离鉴定 

分 类 号：R284[医药卫生—中药学]