Drug-induced severe liver injury due to Sterculia versicolor: a case report with causality assessment from possible to probable  

作　　者：Ling Zhu Jiawei Geng An Xiao 

机构地区：[1]Department of Infectious Diseases and Hepatic Diseases,the First People's Hospital of Yunnan Province,the Affiliated Hospital of Kunming University of Science and Technology,Kunming,Yunnan 650032,China

出　　处：《The Journal of Biomedical Research》2022年第3期215-220,共6页生物医学研究杂志（英文版）

基　　金：the support of Yunnan (Kunming) Zhang Wenhong expert workstation (YSZJGZZ-2020051)

摘　　要：Sterculia gum,the dry exudate of Sterculia versicolor and other members of the same genus,is used as a thickener and emulsifier in foods.It is generally considered safe as a food or drug,and its adverse reactions,such as Sterculia-induced liver injury,have never been reported.A 46-year-old woman was admitted to hospital with fatigue,nausea,abdominal distension,jaundice and a>16-fold increase in transaminase and bilirubin level.The patient had used Sterculia gum prior to the onset of her symptoms.Her symptoms and clinical indicators improved after treatment.The possibility of acute viral hepatitis,autoimmune hepatitis,and metabolic liver disease was excluded.After discharge from hospital,the patient had a severe liver injury again when re-exposed to Sterculia gum.And the Roussel Uclaf Causality Assessment Method score was updated from 5 to 7,which was consistent with probable drug-induced liver injury.This is the first report of Sterculia-induced liver injury.Clinicians need to be aware of the potential hepatotoxicity of Sterculia.

关 键 词：STERCULIA herb-induced liver injury Roussel Uclaf Causality Assessment Method 

分 类 号：R285.6[医药卫生—中药学]