疏肝理气消岩方联合化疗对晚期三阴性乳腺癌的影响  

Effect of Shugan Liqi Xiaoyan Formula(疏肝理气消岩方)Combined with Chemotherapy on Advanced Three Negative Breast Cancer

作　　者：田平[1] 李永安[1] 宣小山 TIAN Ping;LI Yongan;XUAN Xiaoshan(Huainan Oriental Hospital Group Cancer Hospital,Huainan 232085,China)

机构地区：[1]淮南东方医院集团肿瘤医院,安徽淮南232085

出　　处：《山东中医杂志》2022年第6期626-630,共5页Shandong Journal of Traditional Chinese Medicine

基　　金：安徽省重点研究与开发计划项目(编号:202004j07020056)。

摘　　要：目的:研究自拟疏肝理气消岩方联合表柔比星注射液+环磷酰胺注射液(EC)化疗方案对晚期三阴性乳腺癌的影响。方法:选取60例晚期三阴性乳腺癌患者,按随机数字表法分为对照组和观察组各30例。对照组采用单纯EC方案化疗,观察组采用疏肝理气消岩方联合EC方案化疗,比较两组疗效,分析两组治疗前后血清肿瘤标志物糖类抗原153(CA-153)、糖类抗原125(CA-125)、癌胚抗原(CEA)变化,并对比两组不良反应发生情况及生活质量改善情况。结果:观察组有效率为65.52%,明显高于对照组的46.43%(P<0.05);两组治疗后血清CA-153、CA-125、CEA水平均较治疗前降低(P<0.05),且观察组低于对照组(P<0.05)。观察组不良反应发生率为43.33%,明显低于对照组的76.68%(P<0.05)。观察组生活质量评分较对照组显著提高(P<0.05)。结论:疏肝理气消岩方联合化疗对晚期三阴性乳腺癌疗效明显,可有效改善血清肿瘤标志物水平,降低不良反应发生率,提高患者生活质量。Objective:To study the effect of Shugan Liqi Xiaoyan Formula(疏肝理气消岩方)combined with epirubicin injection and cyclophosphamide injection(EC)chemotherapy on advanced three negative breast cancer.Methods:Total 60 patients with advanced three negative breast cancer were divided into the control group and the observation group according to the random number table method,with 30 cases in each group.The control group was treated with EC regimen alone,and the observation group was treated with Shugan Liqi Xiaoyan Formula combined with EC regimen.The effects of the two groups were compared,the changes of serum tumor markers carbohydrate antigen 153(CA-153),carbohydrate antigen 125(CA-125),carcinoembryonic antigen(CEA)before and after treatment were analyzed,and the occurrence of toxic and side effects and the improvement of quality of life were compared between the two groups.Results:The effective rate of the observation group was 65.52%,which was significantly higher than 46.43%of the control group(P<0.05).The levels of CA-153,CA-125 and CEA in the two groups after treatment were lower than those before treatment(P<0.05).After treatment,the observation group were lower than those in the control group(P<0.05).The incidence of toxic and side effects in the observation group was 43.33%,which was significantly lower than 76.68%in the control group(P<0.05).The score of quality of life in the observation group was significantly higher than that in the control group(P<0.05).Conclusions:Shugan Liqi Xiaoyan Formula combined with chemotherapy have obvious effect on advanced three negative breast cancer,which can effectively improve the serum tumor markers level,reduce the incidence of toxic and side effects,and improve the quality of life.

关 键 词：疏肝理气消岩方 三阴性乳腺癌 肝气郁滞 疏肝理气 解毒散结 化疗 增效减毒 

分 类 号：R273.79[医药卫生—中西医结合]