2-(1,3-二氢异苯并呋喃)-1-苯乙酮类衍生物的合成  

Synthesis of 2-(1,3-Dihydroisobenzofuran)-1-acetophenone Derivatives

作　　者：赵美玲 刘芊芊 张翠兰 龙思会 李立[2] 刘娥[2] ZHAO Mei-ling;LIU Qian-qian;ZHANG Cui-lan;LONG Si-hui;LI Li;LIU E(Chemical Engineering and Pharmacy,Wuhan Institute of Technology,Wuhan 430205,China;College of Chemical Engineering and Pharmacy,Jingchu University of Technology,Jingmen 448000,China)

机构地区：[1]武汉工程大学化工与制药学院,湖北武汉430205 [2]荆楚理工学院化工与药学院,湖北荆门448000

出　　处：《化学试剂》2022年第6期926-930,共5页Chemical Reagents

基　　金：湖北省教育厅优秀中青年团队项目(T2021027);荆楚理工学院科研项目(ZD202105);荆楚理工学院研究生科研专项基金项目(YJS202102);荆楚理工学院大学生创新项目(202011336010、S202111336023)。

摘　　要：在钴催化体系下,以邻苯二甲醇和苯乙酮为起始原料,一锅法反应得到2-(1,3-二氢异苯并呋喃)-1-苯乙酮,进而对底物进行拓展,得到标题化合物,并对反应条件进行优化。结果表明,以甲苯为溶剂、叔丁醇钾为碱,钴催化剂用量为10%mol,标题化合物的产率较好。化合物结构经^(1)HNMR和^(13) CNMR确证。该方法具有反应条件温和、操作简单、产率较高的特点。2-[(1,3-Dihydroisobenzofuran)-1-yl]acetophenone was synthesized by the one-pot reaction of phthaloyl alcohol and acetophenone in the cobalt catalyzed system.The reaction conditions were optimized.Target compounds were obtained by expanding the substrates.The results showed that target compounds were obtained in good yields in toluene as solvent with potassium tert-butoxide as base and 10%mol cobalt as catalyst.The structures of the compounds were confirmed by^( 1)HNMR and ^(13) CNMR.The method is characterized as mild reaction conditions,simple operation,and high yield.

关 键 词：钴催化 邻苯二甲醇 一锅法 2-(1 3-二氢异苯并呋喃)-1-苯乙酮 合成 

分 类 号：O625.1[理学—有机化学]