尿血管紧张素原、中性粒细胞明胶酶相关脂质运载蛋白水平在高血压肾病中的变化及临床意义  

Changes and clinical significance of urinary angiotensinogen and neutrophil gelatinase-associated lipocalin levels in hypertensive nephropathy

作　　者：陈姣 崔英[1] 储虹[1] 蒋倩 CHEN Jiao;CUI Ying;CHU Hong;JIANG Qian(Department of Nephrology,Yixing People’s Hospital,Jiangsu Province,Yixing214200,China)

机构地区：[1]江苏省宜兴市人民医院肾脏内科,江苏宜兴214200

出　　处：《中国医药导报》2022年第12期79-81,87,共4页China Medical Herald

基　　金：江苏省自然科学基金青年项目(BK20190601)。

摘　　要：目的探讨尿血管紧张素原(UAGT)、中性粒细胞明胶酶相关脂质运载蛋白(NGAL)水平在高血压肾病中的变化及临床意义。方法选取2018年3月至2021年3月江苏省宜兴市人民医院收治的130例高血压患者,根据是否患有高血压肾病将其分为单纯高血压组(74例)和高血压肾病组(56例)。比较两组临床资料及UAGT、NGAL水平,采用logistic回归模型分析高血压肾病的影响因素,采用受试者操作特征曲线分析UAGT、NGAL水平对高血压肾病的诊断价值。结果高血压肾病组尿微量白蛋白、血肌酐、UAGT、NGAL水平均高于单纯高血压组,差异有统计学意义(P<0.05)。多因素分析结果显示,UAGT、NGAL、尿微量白蛋白均是高血压肾病的独立影响因素(P<0.05)。UAGT、NGAL对高血压肾病均具有一定的诊断价值,曲线下面积分别为0.862、0.869(P<0.05)。结论高血压肾病患者UAGT、NGAL水平均异常升高,且二者均是高血压肾病的独立影响因素,检测UAGT、NGAL水平变化可作为评估高血压肾病的敏感指标。Objective To explore the changes and clinical significance of urinary angiotensinogen(UAGT)and neutrophil gelatinase-associated lipocalin(NGAL)levels in hypertensive nephropathy.Methods A total of 130 hypertensive patients admitted to Yixing People’s Hospital,Jiangsu Province from March 2018 to March 2021 were selected.According to whether they had hypertensive nephropathy,they were divided into simple hypertension group(74 cases)and hypertensive nephropathy group(56 cases).The clinical data,UAGT,and NGAL levels of the two groups were compared.Logistic regression model was used to analyze the influencing factors of hypertensive nephropathy,and the diagnostic value of UAGT and NGAL levels in hypertensive nephropathy was analyzed by receiver operating characteristic curve.Results Levels of urinary microalbumin,serum creatinine,UAGT,and NGAL in hypertensive nephropathy group were higher than those in simple hypertension group,the differences were statistically significant(P<0.05).Multivariate analysis showed that UAGT,NGAL,and urinary microalbumin were independent influencing factors of hypertensive nephropathy(P<0.05).UAGT and NGAL had certain diagnostic value for hypertensive nephropathy,and the area under the curve was 0.862 and 0.869,respectively(P<0.05).Conclusion UAGT and NGAL levels are abnormally elevated in hypertensive nephropathy patients,and both of them are independent influencing factors of hypertensive nephropathy.Detection of changes in UAGT and NGAL levels can be used as sensitive indicators for evaluation of hypertensive nephropathy.

关 键 词：高血压肾病 尿血管紧张素原 中性粒细胞明胶酶相关脂质运载蛋白 

分 类 号：R692[医药卫生—泌尿科学]