血管内皮细胞铁死亡在椎动脉型颈椎病中的作用机制  

Mechanism of vascular endothelial cells ferroptosis in cervical spondylosis of vertebral artery type

作　　者：王凯 宋敏 宋志靖 李金益 WANG Kai;SONG Min;SONG Zhijing;LI Jinyi(Clinical College of Chinese Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;Department of Orthopedics,the Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730020,Gansu,China)

机构地区：[1]甘肃中医药大学中医临床学院,甘肃兰州730000 [2]甘肃中医药大学附属医院骨科,甘肃兰州730020

出　　处：《中国临床药理学与治疗学》2022年第5期588-594,共7页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金(81360554,81760876);甘肃省自然科学基金(1610RJZA069);甘肃省高等学校科学研究项目(2017A-053);甘肃省教育厅优秀研究生“创新之星”项目(2021CXZX-765)。

摘　　要：铁死亡是一种新型的细胞死亡方式,以细胞内铁过载和脂质代谢紊乱为特征,与心脑血管疾病、肿瘤、急性损伤的发生密切相关。机体组织器官处于缺血缺氧状态下,铁离子启动脂质过氧化反应,产生大量氧自由基,一系列氧化应激反应更容易触发铁死亡。而在椎动脉型颈椎病发生过程中,颈椎退行性改变造成的椎动脉供血不足导致铁稳态失衡、氨基酸代谢异常,诱发的铁死亡对病情发展有重要影响。本文就铁死亡在椎动脉型颈椎病发生中的作用机制展开综述,以期为本病相关问题研究提供新的思路与视角。Ferroptosis is a novel type of cell death,characterized by iron overload and lipid metabolism disorders,and is closely related to the occurrence of cardiovascular and cerebrovascular diseases,tumors,and acute injuries.When tissues and organs of the body are in a state of ischemia and hypoxia,iron ions initiate lipid peroxidation and produce a large number of oxygen free radicals.A series of oxidative stress reactions are more likely to trigger ferroptosis.In the process of cervical spondylosis of vertebral artery type,insufficient blood supply to the vertebral artery caused by degenerative changes of the cervical spine leads to imbalance of iron homeostasis and abnormal amino acid metabolism.Then ferroptosis is induced and plays an important role in the development of cervical spondylosis of vertebral artery type.This paper reviewed the mechanism of ferroptosis in the occurrence of cervical spondylosis of vertebral artery type,in order to provide new ideas and perspectives for the study of related problems of the disease.

关 键 词：椎动脉型颈椎病 铁死亡 脂质过氧化 铁稳态 病理机制 

分 类 号：R681.5[医药卫生—骨科学] Q291[医药卫生—外科学]