新型速效抗抑郁药的研究进展  

Advances in new fast-acting antidepressants

作　　者：于泽芳 范理菊 尹晓玉 高丽丽[1] 董占军[1] YU Zefang;FAN Liju;YIN Xiaoyu;GAO Lili;DONG Zhanjun(Hebei General Hospital Department of Pharmacy,Shijiazhuang 050000,Hebei,China)

机构地区：[1]河北省人民医院药学部,河北石家庄050000

出　　处：《中国临床药理学与治疗学》2022年第5期595-600,共6页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：河北省卫健委跟踪项目(GZ2021092);河北省卫健委立项(20190313)。

摘　　要：抗抑郁药主要用于治疗以情绪抑郁为突出症状的精神性疾病。传统的抗抑郁药主要是以单胺类神经递质为靶点,但该类药物显效慢无法满足临床治疗需求。因此,目前临床上治疗抑郁症的方法已经从传统的单胺假说转到谷氨酸能、γ-氨基丁酸、阿片类药物和炎症系统等研究领域。近年来,新型抗抑郁药物的开发取得了很大进展,其中一些药物已逐渐应用于临床。本文汇总了新型抗抑郁药物的研究机制及治疗方案,并对常见的速效抗抑郁药物进行了简单的综述。Antidepressants are mainly used to treat mental illnesses.Traditional antidepressants mainly target monoamine neurotransmitters,but these drugs are slow to be effective and cannot meet clinical needs.Recently,therapeutics have been developed that depart from the traditional monoamine hypothesis and focus on the glutamatergic,GABAergic,opioidergic,and inflammatory systems.In recent years,great progress has been made in the development of new antidepressants,some of which have been applied in clinical practice.This article mainly summarizes the research mechanisms and treatment programs of new antidepressants,and briefly reviews common rapid-acting antidepressants.

关 键 词：抗抑郁药 谷氨酸能系统 γ-氨基丁酸系统 阿片系统 炎症系统 

分 类 号：R971.43[医药卫生—药品]