Facile synthesis of ( β -chlorodifluoroethyl)phosphonates via chlorination reaction of difluoroalkyl diazo derivatives with HCl  

作　　者：Jiang Liu Romana Pajkert Li Wang Haibo Mei Gerd-Volker Röschenthaler Jianlin Han 

机构地区：[1]Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources,International Innovation Center for Forest Chemicals and Materials,College of Chemical Engineering,Nanjing Forestry University,Nanjing 210037,China [2]Department of Life Sciences and Chemistry,Jacobs University Bremen gGmbH,Campus Ring 1,Bremen 28759,Germany

出　　处：《Chinese Chemical Letters》2022年第5期2429-2432,共4页中国化学快报（英文版）

基　　金：supports from the National Natural Science Foundation of China (No. 21761132021);German Research Foundation (No. RO362/74–1);Qin Lan project from Jiangsu Province for JLH is also acknowledged

摘　　要：An efficient chlorination reaction of in situ generated(β-diazo-α,α-difluoroethyl)phosphonates has been achieved with hydrochloric acid as a chlorine source under mild and operationally convenient conditions.The reaction does not need any catalyst and tolerates a wide scope of substrates,which affords the(β-chlorodifluoroethyl)phosphonate products in good to excellent yields.This reaction represents the first example of the halogenation of difluoroalkyl diazo compounds,and also provides an easy way for the synthesis of difluoromethylenephosphonate-containing compounds.

关 键 词：Difluorodiazoethane (β-Diazo-α α-difluoroethyl)phosphonates Halogenation reaction Difluoroalkyl diazo Hydrochloric acid Masked carbene 

分 类 号：TQ225.24[化学工程—有机化工]