移动校正对CZT SPECT心肌血流定量显像影响的初步研究  

Primary study of motion correction effect on myocardial blood flow quantitative imaging with CZT SPECT

作　　者：庞泽堃 汪娇[1] 陈越[1] 王小杰 李帅[1] 李剑明[1] Pang Zekun;Wang Jiao;Chen Yue;Wang Xiaojie;Li Shuai;Li Jianming(Department of Nuclear Medicine,TEDA International Cardiovascular Hospital and Tianjin Medical University Clinical Cardiovascular Institute,Tianjin 300457,China)

机构地区：[1]天津医科大学心血管病临床学院、泰达国际心血管病医院核医学科,天津300457

出　　处：《中华核医学与分子影像杂志》2022年第5期279-283,共5页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：天津市滨海新区卫生健康委员会科技项目(2017BWKY025)。

摘　　要：目的探讨移动校正(MC)对碲锌镉SPECT(CZT SPECT)心肌血流(MBF)和心肌血流储备(MFR)计算值的影响。方法回顾性收集2019年6月至2019年8月于泰达国际心血管病医院行动态CZT SPECT心肌灌注显像(MPI)的可疑或确诊冠状动脉粥样硬化性心脏病(简称冠心病)患者28例[男10例,女18例,年龄(60.75±11.62)岁]。经定量分析获得静息、负荷显像的MBF和MFR值,应用Corridor 4DM软件计算MC前后冠状动脉各分支区域及左心室(LV)整体的负荷MBF(sMBF)和MFR,对数据进行配对t检验和Pearson相关分析。结果MC前患者LV整体的sMBF和MFR分别为(0.82±0.49)ml·min^(-1)·g^(-1)和1.69±0.68,而MC后这2个指标计算值增加,分别为(1.05±0.64)ml·min^(-1)·g^(-1)和2.12±0.77(t值:-4.87、-6.01,均P<0.001)。MC前与MC后患者左前降支(LAD)、左回旋支(LCX)、右冠状动脉(RCA)区域及LV整体的sMBF、MFR均有较佳的相关性(r值:0.69~0.96,均P<0.001)。若以MFR<2.0作为血流储备受损参考标准,28例中有19例(67.9%)MC前存在MFR受损,而MC后有13例(46.4%)存在此情况。结论在CZT SPECT MPI定量显像中,MC后sMBF及MFR计算值较MC前提高,MC有助于减少心脏"爬升"效应可能导致的假阳性。Objective To investigate the effect of motion correction(MC)on the calculated values of myocardial blood flow(MBF)and myocardial flow reserve(MFR)based on cadmium-zinc-telluride SPECT(CZT SPECT)images.Methods Twenty-eight consecutive patients(10 males,18 females,age:(60.75±11.62)years)with suspected or known coronary artery disease who underwent myocardial perfusion imaging(MPI)with dynamic CZT SPECT between June 2019 and August 2019 in TEDA International Cardiovascular Hospital were retrospectively analyzed.The MBF and MFR during rest imaging and stress imaging were quantitatively analyzed.Corridor 4DM software was used to calculate the stress MBF(sMBF)and MFR of the coronary artery branches and left ventricular(LV)before and after MC.The paired t test and Pearson correlation were used for data analysis.Results The sMBF and MFR of LV before MC were(0.82±0.49)ml·min^(-1)·g^(-1) and 1.69±0.68 respectively.After MC the two parameters increased to(1.05±0.64)ml·min^(-1)·g^(-1) and 2.12±0.77 respectively(t values:-4.87,-6.01,both P<0.001).The sMBF and MFR in left anterior descending(LAD),left circumflex(LCX),right coronary artery(RCA)and LV before MC were correlated with those after MC(r values:0.69-0.96,all P<0.001).If MFR<2.0 was used as the reference of impaired MFR,data before MC showed 19 patients(67.9%,19/28)had impaired MFR,while 13 patients(46.4%,13/28)had impaired MFR based on MFR values after MC.Conclusion For MPI quantitative imaging with CZT SPECT,the calculated values of sMBF and MFR after MC is higher than those before MC,suggesting that MC is helpful to reduce the false positive results which may be caused by the"creep"effect of the heart.

关 键 词：心肌血流 右冠状动脉 Pearson相关分析 左前降支 左回旋支 血流储备 CZT SPECT 

分 类 号：R817.4[医药卫生—影像医学与核医学] R541.4[医药卫生—放射医学]