药物饲料添加剂吉他霉素耐药性风险评估  

Risk assessment of kitasamycin resistance as a medicated feed additive

作　　者：周旎 何梦如 吕晓华 ZHOU Ni;HE Meng-ru;LV Xiao-hua(不详;West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu,Sichuan 610041,China)

机构地区：[1]四川大学华西公共卫生学院/华西第四医院,四川成都610041 [2]不详

出　　处：《现代预防医学》2022年第10期1770-1774,共5页Modern Preventive Medicine

基　　金：四川省科技计划项目(2019YFS0062)。

摘　　要：目的为给兽药减量政策的制定、动物源性食品安全的维护提供理论依据。方法利用每日允许摄入量(ADI)、估算每日摄入量(EDI)及慢性风险熵(CRQ),对中国居民通过摄入肉蛋乳等动物性食品暴露于吉他霉素的耐药性风险进行点评估。结果随着年龄增长,中国居民的吉他霉素膳食暴露量逐渐降低。2~7岁人群吉他霉素的膳食暴露量最高,男女分别为2.17和2.29μg/(kg·bw·d);>65岁人群膳食暴露量最低,男女分别为0.45和0.46μg/(kg·bw·d)。2~7岁人群通过摄入乳制品的吉他霉素的膳食暴露量最大,男女分别为1.15和1.22μg/(kg·bw·d),8岁以上人群通过摄入肉类食品的吉他霉素的膳食暴露量最大。中国居民通过摄入肉蛋乳等动物性食品暴露于吉他霉素,各年龄段CRQ均小于1。其中2~7岁人群CRQ值最高,风险最大;65岁以上人群CRQ值最低,风险最小。结论中国居民通过摄入动物性食品的吉他霉素耐药性风险较低,危害程度较小,但儿童通过摄入乳制品的吉他霉素耐药性风险较高,有必要制定乳制品中吉他霉素残留的限量标准。Objective To provide a theoretical basis for formulating veterinary drug reduction policies and the maintenance of animal-derived food safety.Methods A point assessment of the risk of kitasamycin resistance in Chinese residents exposed to animal foods such as meat,eggs and dairy was conducted using the Acceptable Daily Intake(ADI),Estimated Daily Intake(EDI)and Chronic Risk Entropy(CRQ).Results Dietary exposure to kitasamycin decreased with age in the Chinese population.The dietary exposure of kitasamycin was highest for those aged 2 to 7 years,at 2.17and 2.29μg/(kg bw·d)for males and females respectively,and lowest for those aged>65 years,at 0.45 and 0.46μg/(kg bw·d)for those aged 2 to 7 years.The Dietary exposur to kitasamycin was highest in the population aged 2 to 7 years,with 1.15 and 1.22μg/(kg bw·d)for males and females,respectively.The dietary exposure to kitasamycin through the intake of meat foods was highest in the population aged 8 years and above.Chinese residents were exposed to kitasamycin through ingestion of animal foods such as meat,eggs,and dairy.The CRQ and the risk were the highest for people aged 2 to 7;while the CRQ was the lowest for people over 65 and the risk was the smallest.The CRQ was less than 1 for all ages.Conclusion The risk of kitasamycin resistance in Chinese residents through ingestion of animal foods is low and the hazard level is low,but the risk of kitasamycin resistance in children through ingestion of dairy products is high and there is a need to establish limits for kitasamycin residues in dairy products.

关 键 词：吉他霉素 药物饲料添加剂 风险评估 

分 类 号：S816.3[农业科学—饲料科学]