碘及甲状腺功能与机体脂代谢关系的研究进展  

Research progress on the relationship between iodine,thyroid function and lipid metabolism

作　　者：翟玉倩 刘智勇 范丽珺 Zhai Yuqian;Liu Zhiyong;Fan Lijun(Institute for Iodine Deficiency Disorders Control,Center for Endemic Disease Control,Chinese Center for Disease Control and Prevention,Key Laboratory of National Health Commission for Etiology and Epidemiology,Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学中国疾病预防控制中心地方病控制中心碘缺乏病防治研究所,国家卫生健康委病因流行病学重点实验室,哈尔滨150081

出　　处：《中华地方病学杂志》2022年第5期420-424,共5页Chinese Journal of Endemiology

基　　金：国家自然科学基金(82173638);黑龙江自然科学基金团队项目(TD2019H001)。

摘　　要：碘是甲状腺激素生物合成必不可少的组成部分,对机体的生长、发育、成熟以及器官和系统的功能具有重要作用。流行病学及动物实验研究表明,碘对机体的作用是双向的,碘摄入不足和摄入过量都会引起不良后果,进而影响人体健康。目前,碘营养异常对人体健康危害的研究大多集中在对甲状腺形态、功能等方面,而实际上,碘营养异常不仅对甲状腺有影响,对机体其他方面也有诸多不利作用。目前有证据表明,碘营养异常与血脂异常、心血管疾病之间存在联系,会导致体内甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇等含量异常。本文就碘营养及甲状腺功能与机体脂代谢关系方面的研究进行综述,以期为我国碘缺乏病"科学、精准"防治提供理论依据。Iodine is an essential component of thyroid hormone biosynthesis.It plays an important role in the growth,development,maturation and the function of organs and systems.Epidemiological and animal studies have shown that the effect of iodine on human body is bidirectional.Insufficient and excessive intake of iodine will cause adverse consequences and affect human health.At present,the research on the harm of iodine nutritional abnormalities to human health mostly focuses on morphology and function of thyroid.In fact,iodine nutritional abnormalities not only affect thyroid,but also have many adverse effects on other aspects of the body.There is evidence of a link between abnormal iodine nutrition,dyslipidemia and cardiovascular disease,which will lead to abnormal levels of triglycerides,high-density lipoprotein cholesterol,and low-density lipoprotein cholesterol in the body.This paper reviews the research progress on the relationship between iodine nutrition,thyroid function and body lipid metabolism,in order to provide a theoretical basis for the"scientific and precise"prevention and treatment of iodine deficiency disorders in China.

关 键 词：碘营养 碘缺乏 碘过量 脂代谢 血脂 

分 类 号：R599[医药卫生—内科学]