肽类树状大分子的功能化修饰及在肿瘤治疗和诊断中的应用综述  

Functionalization of Peptide Dendrimers and Its Application in Tumor Treatment and Diagnosis:a Review

作　　者：王朋飞 徐胜楠 魏杰 刘文娟 顾忠伟[1] 张亚男 WANG Pengfei;XU Shengnan;WEI Jie;LIU Wenjuan;GU Zhongwei;ZHANG Yanan(School of Materials Science and Engineering,Nanjing University of Technology,Nanjing 211816,China)

机构地区：[1]南京工业大学材料科学与工程学院,南京211816

出　　处：《材料导报》2022年第11期215-222,共8页Materials Reports

基　　金：江苏省自然科学基金(BK20180698,BK20180495)。

摘　　要：肽类树状大分子是一类具有高度规整性、三维结构、尺寸可控的大分子。其由于良好的生物相容性、低免疫原性和多功能化等特点,近几十年来逐渐发展成一类新型生物医用高分子材料。目前,基于肽类树状大分子的药物递送系统,在药物/基因负载、靶向递送及释放等方面取得了突破性进展。抗癌药物/基因可通过物理包埋或环境敏感型化学键与肽类树状大分子结合,进而通过高渗透长滞留效应(EPR效应)或借助靶向因子实现向肿瘤部位的有效递送,最后通过载体溶胀或敏感型化学键的断裂实现药物释放。为达到更有效的抗肿瘤治疗效果,设计更加稳定、精准及具有诊疗一体或联合治疗功能的肽类树状大分子药物递送系统是目前研究的热点和难点。本文简单介绍了近几年来肽类树状大分子表面功能化的研究进展,以及肽类树状大分子药物载体在治疗和诊断领域的应用。Peptide dendrimers are a three-dimensional nano-sized high-regularity macromolecule with tunable size. In recent years,due to their numerous advantages such as biocompatibility,low immunogenicity,multiple functional groups at the periphery and so on,peptide dendrimers have become a novel biomedical polymer material.Breakthroughs have been made in drug/gene loading,targeted delivery and release by developing great peptide dendrimer-based nanotherapeutics. Anticancer drugs/genes can be either encapsulated in or conjugated to dendrimer and be delivered to the tumor via enhanced permeability and retention effect( EPR) or with the help of the targeting moiety. Finally,the drugs can be released by the drug delivery systems with more stable and precise therapeutic effect has been extensively studied,while it still remains a challenging issue. In order to achieve more effective antitumor treatment effect,design the more stable,accurate and peptide dendrimer drug delivery system with integrated or combined diagnosis and treatment function is a current research hotspot and difficulty.In this paper,a brief introduction of surface functionalization progress of peptide dendrimers is presented. Then,their promising application in therapeutic and diagnostic fields as drug carrier is summarized.

关 键 词：肽类树状大分子 功能化 药物靶向递送 癌症治疗 癌症诊断 

分 类 号：R318.08[医药卫生—生物医学工程]