微波消融术对混合性良性甲状腺结节的疗效研究  

Study on the efficacy of microwave ablation on mixed benign thyroid nodules

作　　者：古东海[1] 李子怡 庞若宇 GU Dong-hai;LI Zi-yi;PANG Ruo-yu(Department of Endocrinology and Metabolism,Maoming People's Hospital,Maoming 525000,China)

机构地区：[1]茂名市人民医院内分泌代谢内科,525000

出　　处：《中国现代药物应用》2022年第7期17-20,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探讨混合性良性甲状腺结节患者采用微波消融术治疗的效果。方法80例混合性良性甲状腺结节患者,采用随机数字表法分为对照组和观察组,各40例。对照组采用常规切除手术治疗,观察组采用微波消融术治疗。比较两组患者临床疗效、术后并发症发生情况、手术时间和术中出血量,治疗前后结节体积、促甲状腺激素和游离甲状腺素水平。结果观察组患者的治疗总有效率95.0%显著高于对照组的80.0%,差异具有统计学意义(P<0.05)。观察组患者的并发症发生率2.5%显著低于对照组的15.0%,差异具有统计学意义(P<0.05)。观察组患者的手术时间(36.82±4.51)min短于对照组的(62.08±4.02)min,术中出血量(12.69±2.84)ml少于对照组的(27.84±2.34)ml,差异具有统计学意义(P<0.05)。治疗前,两组的结节体积比较差异无统计学意义(P>0.05);治疗后,两组患者的结节体积均明显小于治疗前,且观察组患者的结节体积(0.42±0.08)cm^(3)小于对照组的(0.84±0.11)cm^(3),差异具有统计学意义(P<0.05)。治疗前,两组患者的促甲状腺激素和游离甲状腺素水平比较差异无统计学意义(P>0.05);治疗后,两组患者的促甲状腺激素水平明显高于治疗前,游离甲状腺素水平明显低于治疗前,且观察组患者的促甲状腺激素水平(4.89±1.46)mIU/L高于对照组的(3.55±1.35)mIU/L,游离甲状腺素水平(30.47±3.95)pmol/L低于对照组的(41.17±3.02)pmol/L,差异具有统计学意义(P<0.05)。结论混合性良性甲状腺结节患者采用微波消融术治疗兼具有效性和安全性,可缩短手术时间、减少术中出血量,同时可减小结节体积,改善甲状腺激素水平,总体治疗优势显著,因此,此种治疗方法值得在临床上进一步推广应用。Objective To discuss the effect of microwave ablation on patients with mixed benign thyroid nodules.Methods A total of 80 patients with mixed benign thyroid nodules were randomly divided into control group and observation group by random numerical table,with 40 cases in each group.The control group was treated with conventional resection,and the observation group was treated with microwave ablation.Both groups were compared in terms of clinical efficacy,postoperative complications,operation time and intraoperative blood loss,nodule volume and thyroid stimulating hormone and free thyroxine.Results The total effective rate in the observation group was 95.0%,which was significantly higher than 80.0%in the control group,and the difference was statistically significant(P<0.05).The complication rate in the observation group was 2.5%,which was significantly lower than 15.0%in the control group,and the difference was statistically significant(P<0.05).The operation time(36.82±4.51)min of the observation group was shorter than(62.08±4.02)min of the control group,and the intraoperative blood loss(12.69±2.84)ml was less than(27.84±2.34)ml of the control group.All the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in nodule volume between the two groups(P>0.05).After treatment,the nodule volume of the two groups was significantly smaller than that before treatment,and the nodule volume(0.42±0.08)cm^(3) of the observation group was smaller than(0.84±0.11)cm^(3) of the control group.All the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in thyroid-stimulating hormone and free thyroxine between the two groups(P>0.05).After treatment,the thyroid-stimulating hormone in the two groups were significantly higher than those before treatment in this group,and the free thyroxine was significantly lower than that before treatment in this group;the thyroid-stimulating hormone(4.89±1.46)mIU/L

关 键 词：微波消融术 混合性良性甲状腺结节 临床疗效 

分 类 号：R653[医药卫生—外科学]