大剂量甲氨蝶呤的临床用药研究  

Clinical study of high-dose methotrexate

作　　者：侯丽萍 HOU Li-ping(Yangpu Hospital Affiliated to Tongji University,Shanghai 200090,China)

机构地区：[1]同济大学附属杨浦医院,200090

出　　处：《中国现代药物应用》2022年第7期107-109,共3页Chinese Journal of Modern Drug Application

摘　　要：目的研究大剂量甲氨蝶呤治疗急性白血病效果及安全性。方法46例急性白血病患者,应用颜色卡片分组法分为对照组(红色卡片)和观察组(蓝色卡片),每组23例。对照组给予15 mg/m^(2)甲氨蝶呤治疗,观察组给予25 mg/m^(2)甲氨蝶呤治疗。比较两组患者毒副反应发生情况、治疗效果。结果两组肝功能损害、胃肠道不适、皮肤损害发生率比较差异无统计学意义(P>0.05)。观察组治疗总有效率为95.65%,高于对照组的73.91%,差异具有统计学意义(P<0.05)。结论大剂量甲氨蝶呤在临床急性白血病中的应用效果明显,结合四氢叶酸钙解救能够保证用药安全性,值得在临床推广应用。Objective To study the effect and safety of high-dose methotrexate in the treatment of acute leukemia.Methods A total of 46 patients with acute leukemia were divided into control group(red card)and observation group(blue card)by color card grouping method,with 23 cases in each group.The control group was treated with 15 mg/m^(2) methotrexate,and the observation group was treated with 25 mg/m^(2) methotrexate.The incidence of toxic and side effects and therapeutic effects were compared between the two groups.Results There was no statistically significant difference in the incidence of liver function damage,gastrointestinal discomfort and skin damage between the two groups(P>0.05).The total effective rate of the observation group was 95.65%,which was higher than 73.91%of the control group,and the difference was statistically significant(P<0.05).Conclusion High-dose methotrexate has obvious effect in clinical treatment of acute leukemia,and it can ensure the drug safety combing with calcium tetrahydrofolate,which is worthy of clinical promotion and application.

关 键 词：甲氨蝶呤 急性白血病 大剂量 效果 安全性 

分 类 号：R979.1[医药卫生—药品]