TGF-β1、TNF-α、IL-4、IL-6在早期胚胎停育中的意义  

Significance of TGF-β1, TNF-α, IL-4 and IL-6 in Early Embryo Arrest

作　　者：金力荣[1] 杨麦青 徐洪波[4] 魏燕妮 JIN Li-rong;YANG Mai-qing;XU Hong-bo;WEI Yan-ni(Department of Obstetrics,Changyi People's Hospital,Changyi 261300,Shandong,China;Department of Pathology,Changyi People's Hospital,Changyi 261300,Shandong,China;Department of Pathology,Weifang People’s Hospital,Weifang 261041,Shandong,China;Department of Blood Transfusion,Changyi People's Hospital,Changyi 261300,Shandong,China;Department of Health Management,Weifang Nursing Vocational College,Weifang 261041,Shandong,China)

机构地区：[1]昌邑市人民医院产科,山东昌邑261300 [2]昌邑市人民医院病理科,山东昌邑261300 [3]潍坊市人民医院病理科,山东潍坊261041 [4]昌邑市人民医院输血科,山东昌邑261300 [5]潍坊护理职业学院健康管理系,山东潍坊261041

出　　处：《医学信息》2022年第11期93-96,共4页Journal of Medical Information

摘　　要：目的观察早期胚胎停育患者血清中转化生长因子β1(TGF-β1)、肿瘤坏死因子(TNF-α)、白细胞介素4(IL-4)和白细胞介素6(IL-6)的表达水平,探讨其在早期胚胎停育中的作用。方法选取2018年1月-2021年8月在昌邑市人民医院确诊的早期胚胎停育患者35例作为观察组,并选取35例同期正常孕妇为对照组,比较两组TGF-β1、TNF-α、IL-4、IL-6的表达情况,分析TGF-β1、TNF-α、IL-4、IL-6与临床指标的关系及TGF-β1的表达与TNF-α、IL-4、IL-6的关系。结果观察组血清TGF-β1、IL-4、IL-6的表达低于对照组,TNF-α的表达高于对照组(P<0.05);TGF-β1、TNF-α、IL-4、IL-6的表达与年龄、孕周、停经天数、孕囊大小均无关(P>0.05);TGF-β1的表达与IL-4(r=0.368)、IL-6(r=0.338)的表达呈正相关,与TNF-α的表达呈负相关(r=-0.329)。结论早期胚胎停育患者血清中TGF-β1、IL-4、IL-6的表达较正常孕妇降低,TNF-α的表达升高;TGF-β1的表达分别与IL-4、IL-6的表达呈正相关,与TNF-α的表达呈负相关。Objective To observe the expression of transforming growth factor-β1(TGF-β1),tumor necrosis factor-α(TNF-α),interleukin-4(IL-4)and interleukin-6(IL-6)in serum of patients with early embryo arrest,and to explore its role in early embryo arrest.Methods A total of 35 patients with early embryo arrest diagnosed in Changyi People's Hospital from January 2018 to August 2021 were selected as the observation group,and 35 normal pregnant women at the same period were selected as the control group.The expressions of TGF-β1,TNF-α,IL-4 and IL-6 were compared between the two groups.The relationship between TGF-β1,TNF-α,IL-4,IL-6 and clinical indicators and the relationship between TGF-β1 expression and TNF-α,IL-4,IL-6 were analyzed.Results The expression of serum TGF-β1,IL-4 and IL-6 in the observation group was lower than that in the control group,and the expression of TNF-αwas higher than that in the control group(P<0.05).The expression of TGF-β1,TNF-α,IL-4 and IL-6 was not correlated with age,gestational age,amenorrhea days and gestational sac size(P>0.05).The expression of TGF-β1 was positively correlated with the expressions of IL-4(r=0.368)and IL-6(r=0.338),and negatively correlated with the expression of TNF-α(r=-0.329).Conclusion The expression of TGF-β1,IL-4 and IL-6 in serum of patients with early embryo abortion is lower than that of normal pregnant women,and the expression of TNF-αis higher.The expression of TGF-β1 is positively correlated with the expression of IL-4 and IL-6,respectively,and negatively correlated with the expression of TNF-α.

关 键 词：早期胚胎停育 TGF-Β1 TNF-Α IL-4 IL-6 

分 类 号：R714[医药卫生—妇产科学]