薄荷醇对TRPM8小鼠呼吸道上皮短路电流的影响  

THE EFFECT OF MENTHOL ON THE SHORT-CIRCUIT CURRENT OF TRPM8 MOUSE RESPIRATORY EPITHELIUM

作　　者：郅琳[1] 臧文华[1] 张雪鹏[1] 胡久略[1] ZHI Lin;ZANG Wen-hua;ZHANG Xue-peng;HU Jiu-lue(Henan Key Laboratory of Zhang Zhongjing Formulae and Herbs for Immunoregulation,Nanyang Institute of Technology,Nanyang 473004,China)

机构地区：[1]南阳理工学院张仲景方药与免疫调节重点实验室,河南南阳473004

出　　处：《南阳理工学院学报》2022年第2期115-118,共4页Journal of Nanyang Institute of Technology

摘　　要：目的:研究薄荷醇(Menthol)对小鼠呼吸道上皮短路电流的影响。方法:运用短路电流(Isc)技术观察薄荷醇对TRPM8+/+和TRPM8-/-小鼠呼吸道上皮离子转运的改变。结果:薄荷醇浓度依赖性地降低TRPM8+/+小鼠气道上皮Isc,而TRPM8-/-小鼠无此反应。Objective:To study the effect of menthol on the short-circuit current of mouse respiratory epithelium.Methods:the short-circuit current(ISC)technique was used to observe the changes of menthol on the ion transport of TRPM8+/+、TRPM8-/-mice respiratory epithelium.Results:Menthol decreased the ISC of TRPM8+/+mice in a concentration dependent manner,but TRPM8-/-mice did not.

关 键 词：薄荷醇 呼吸道上皮 短路电流 

分 类 号：R3[医药卫生—基础医学]