不同剂量活性维生素D对慢性肾病患者白蛋白、甲状旁腺激素及心肺功能的影响  

Effects of different doses of active vitamin D on albumin,parathyroid hormone and cardiopulmonary function in patients with chronic nephropathy

作　　者：康梅子 沈良兰[1] 薛海燕 房星星[1] KANG Mei-zi;SHEN Liang-lan;XUE Hai-yan;FANG Xing-xing(Department of Nephrology,Nantong First People's Hospital,Nantong 226001,Jiangsu,China)

机构地区：[1]南通市第一人民医院肾内科,江苏南通226001

出　　处：《川北医学院学报》2022年第5期625-629,共5页Journal of North Sichuan Medical College

基　　金：江苏省南通市卫生健康委员会科研课题(MA2020004;QA2021015)。

摘　　要：目的:探讨不同剂量活性维生素D对慢性肾病患者白蛋白、甲状旁腺激素及心肺功能的影响。方法:选取150例慢性肾病患者为研究对象,根据治疗方式不同分为A组、B组和C组,每组各50例。A组患者采用常规治疗+0.5 g/d活性维生素D治疗;B组患者采用常规治疗+0.25 g/d活性维生素D治疗;C组患者仅采用常规治疗。疗程均为6个月。比较3组患者血清白蛋白、血浆甲状旁腺素水平、心肺功能指标[左心室射血分数(LVEF)及动脉血氧分压(PaO_(2))]、6分钟步行距离(6MWD)及生活质量[肾脏疾病生活质量简表(KDQOL-SF^(TM)1.3)及SF-36健康调查简表(SF-36)评分]。结果:治疗6个月后,患者血清白蛋白:A组>B组>C组(P<0.05);甲状旁腺激素:A组<B组<C组(P<0.05);LVEF和PaO_(2):A组>B组>C组(P<0.05);6MWD:A组>B组>C组(P<0.05);KDQOL-SF^(TM)1.3和SF-36评分:A组>B组>C组(P<0.05)。结论:慢性肾病患者在常规治疗基础上补充0.5 g/d剂量的维生素D治疗可改善血清白蛋白和血浆甲状旁腺素的水平,有利于心肺功能的恢复,增强心肺活动耐力,提高患者生活质量,改善预后。Objective:To explore the effects of different doses of active vitamin D on albumin,parathyroid hormone and cardiopulmonary function in patients with chronic nephropathy.Methods:A total of 150 patients with chronic kidney disease were selected as the research objects.They were divided into group A,group B and group C according to different treatment methods,with 50 cases in each group.Patients in group A were given 0.5 g/d dose of active vitamin D on the basis of routine treatment,and patients in group B were given active vitamin D dose of 0.25 g/d on the basis of routine treatment.Patients in group C only received routine treatment and were not given active vitamin D.The course of treatment was 6 months.The levels of serum albumin,plasma parathyroid hormone,cardiopulmonary function[left ventricular ejection fraction(LVEF)and arterial oxygen partial pressure(PaO_(2))],6-minute walking distance(6 MWD)and quality of life[Renal disease quality of life(KDQOL-SF^(TM)1.3)and SF-36 Health Survey(SF-36)scores]were compared between the three groups.Results:After 6 months of treatment,the level of serum albumin in group A and group B was significantly higher than that in group C,and group A was higher than group B(P<0.05).The level of parathyroid hormone in group A was lower than that in group B and group C,and the group B was lower than group C(P<0.05).LVEF and PaO_(2)in group A and group B were significantly higher than those in group C,and group A were higher than group B(P<0.05).The 6 MWD of group A and group B was significantly higher than that in group C,and group A was higher than group B(P<0.05).The scores of KDQOL-SF^(TM)1.3 and SF-36 in group A and group B increased compared with group C(P<0.05).The score of KDQOL-SF^(TM)1.3 and SF-36 in group A and group B were significantly higher than those in group C,and group A were higher than group B(P<0.05).Conclusion:Vitamin D supplementation with 0.5 g/d dose can improve the levels of serum albumin and plasma parathyroid hormone in patients with chronic kidney disease,wh

关 键 词：维生素D 慢性肾病 白蛋白 甲状旁腺激素 心肺功能 

分 类 号：R692[医药卫生—泌尿科学]