射血分数保留型心力衰竭动物模型的研究进展  

Research advances in animal models of heart failure with preserved ejection fraction

作　　者：李慧颖 缪荣 肖湖南 白永怿[1] 刘宏斌[1] LI Huiying;MIAO Rong;XIAO Hu'nan;BAI Yongyi;LIU Hongbin(Department of Cardiology,the Second Medical Center&National Clinical Research Center for Geriatric Diseases,Chinese PLA General Hospital,Beijing 100853,China;Chinese PLA Medical School,Beijing 100853,China;Outpatient Department of Chaoyang 6th Retired Cadres Center of Beijing Garrison,Beijing 100027,China)

机构地区：[1]解放军总医院第二医学中心心血管内科,国家老年疾病临床医学研究中心,北京100853 [2]解放军医学院,北京100853 [3]北京卫戍区朝阳第六离职干部休养所门诊部,北京100027

出　　处：《解放军医学院学报》2022年第3期360-365,共6页Academic Journal of Chinese PLA Medical School

基　　金：国家工信部产业技术基础公共服务平台项目(2020-0103-3-1);解放军后勤应用基础研究重点项目(17BJZ48)。

摘　　要：临床中一半以上的心力衰竭为射血分数保留型心力衰竭(heart failure with preserved ejection fraction,HFpEF)。HFpEF发病机制复杂,且近年来其临床治疗方法没有较大突破。目前HFpEF相关的病理生理机制和治疗方法的研究受限于HFpEF动物模型的建立。本文分类总结了建立HFpEF动物模型的常用方法及研究进展,其中以代谢综合征为特点的动物模型是该领域的流行方向。More than half of patients with heart failure have preserved ejection fraction.The pathogenesis of heart failure with preserved ejection fraction(HFpEF)is complex,while there is no great breakthrough in its treatment in recent years.At present,the research on the pathophysiological mechanism and treatment of HFPEF is limited by the establishment of proper HFPEF animal models.This paper summarizes the common methods and research advances in establishing HFPEF animal models,in which the models with characteristics of metabolic syndrome seems to become a popular direction in this field.

关 键 词：射血分数保留型心力衰竭 实验动物模型 压力负荷 心肌缺血 代谢综合征 

分 类 号：R541.6[医药卫生—心血管疾病]