清热解毒方佐治痰热闭肺型难治性肺炎支原体肺炎临床效果  

Clinical effect of Qingre Jiedu Prescription adjunctive therapyc to refractory mycoplasma pneumoniae pneumonia with syndrome of phlegm and heat blocking the lung

作　　者：杨会荣[1] 张应谦[1] 黄坤玲[1] 赵紫薇 牛波[1] 王乐[1] 路素坤[1] 刘建华[1] YANG Huirong;ZHANG Yingqian;HUANG Kunling;ZHAO Ziwei;NIU Bo;WANG Le;LU Sukun;LIU Jianhua(Department of Pneumology,Children’s Hospital of Hebei Province,Hebei Province,Shijiazhuang 050031,China)

机构地区：[1]河北省儿童医院呼吸科,河北石家庄050031

出　　处：《中国医药导报》2022年第14期146-149,共4页China Medical Herald

基　　金：河北省中医药管理局科研计划项目(2020265)。

摘　　要：目的探讨清热解毒方佐治痰热闭肺型难治性肺炎支原体肺炎(RMPP)临床效果。方法选取2019年11月至2021年2月在河北省儿童医院呼吸科诊断为RMPP患儿60例,将其按照随机数字表法分为对照组和治疗组,每组30例。对照组给予阿奇霉素、糖皮质激素及软式气管镜介入等治疗,治疗组在对照组治疗基础上加服清热解毒方中药7 d。分别记录两组患儿退热、咳嗽明显减轻、肺部呼吸音恢复时间,检测治疗前后血中白细胞(WBC)、C反应蛋白(CRP)、乳酸脱氢酶(LDH)和肺泡灌洗液(BALF)中MP-RNA变化。结果治疗组退热、咳嗽明显减轻及肺部呼吸音恢复时间短于对照组,差异有统计学意义(P<0.05)。治疗前,两组WBC、CRP、LDH比较,差异无统计学意义(P>0.05);治疗后,两组WBC、CRP、LDH较治疗前降低,且治疗组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组低菌量、无菌者例数均多于治疗前,且治疗组多于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论清热解毒方治疗儿童RMPP效果显著,可减低炎症指标,同时减少BALE中MP-RNA病菌量。Objective To explore the clinical effect of Qingre Jiedu Prescription adjunctive therapyc to refractory mycoplasma pneumoniae pneumonia(RMPP)with syndrome of phlegm and heat blocking the lung.Methods A total of 60 children diagnosed with RMPP in the Department of Pneumology,Children’s Hospital of Hebei Province from November 2019 to February 2021 were selected and they were divided into control group and treatment group according to random number table method,with 30 children in each group.The control group was treated with Azithromycin,Glucocorticoid and flexible tracheoscopic intervention,and the treatment group was additionally treated with Qingrejiedu Prescription for seven days.Fever reduction,cough relief and pulmonary breath sound recovery time were recorded in the two groups,and white blood cell(WBC),C-reactive protein(CRP),lactate dehydrogenase(LDH)levels in blood and the changes of MP-RNA in bronchoalveolar lavage fluid(BALF)before and after treatment were detected.Results The fever reduction,cough relief and pulmonary breath sound recovery time in the treatment group was shorter than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in WBC,CRP,and LDH between the two groups(P>0.05).After treatment,WBC,CRP,and LDH in the two groups were lower than those before treatment,and those in the treatment group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the number of patients with low bacterial count and sterility in both groups was higher than before treatment,and the number of patients in treatment group was higher than that in control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Qingre Jiedu Prescription has a significant therapeutic effect on RMPP in children,which can reduce the inflammatory index and the amount of

关 键 词：清热解毒方 痰热闭肺证 难治性肺炎支原体肺炎 肺泡灌洗液 支原体RNA 

分 类 号：R256.1[医药卫生—中医内科学]