畲药铜丝藤根化学成分的分离鉴定  

Isolation and identification of chemical constituents from she medicine Lygodium root

作　　者：张晓芹[1] 袁宙新[1] 倪京丽[1] 王娜妮[2] ZHANG Xiaoqin;YUAN Zhouxin;NI Jingli;WANG Nani(Department of Pharmacy,Lishui Hospital of Traditional Chinese Medicine,Zhejiang Province,Lishui323000,China;Zhejiang Academy of Traditional Chinese Medicine,Zhejiang Province,Hangzhou310007,China)

机构地区：[1]浙江省丽水市中医院药剂科,浙江丽水323000 [2]浙江省中医药研究院,浙江杭州310007

出　　处：《中国医药导报》2022年第13期25-28,共4页China Medical Herald

基　　金：浙江省公益技术应用研究计划项目(LGF19H280002);浙江省丽水市重点研发科技计划项目(2019ZDYF25);浙江省丽水市科技创新团队建设项目(2018cxtd06)。

摘　　要：目的 研究畲药铜丝藤根的化学成分。方法 采用正相硅胶柱层析、制备型高效液相色谱等技术手段,分离纯化铜丝藤根乙醇提取物,运用氢-1核磁共振波谱法、碳-13核磁共振等技术进行结构鉴定。结果 共分离到13个化合物,鉴定为:6-羟基-2-异丙基-7-甲基-1,4-萘醌(1)、原儿茶醛(2)、吐叶醇(3)、(E)-3,4-二羟基苯亚甲基丙酮(4)、对羟基肉桂酸(5)、3-氯-4-羟基-苯甲酸(6)、山柰酚-3-O-芸香糖苷(7)、对羟基苯甲醛(8)、胡萝卜苷(9)、对羟基亚苄基丙酮(10)、3,4-二羟基苯甲酸甲酯(11)、没食子酸甲酯(12)、4-甲氧基-6-(3’,4’-二羟基苯乙烯基)-2-吡喃(13)。结论 2~8、10~13为首次从海金沙属植物中分离得到的化合物。Objective To study the chemical constituents of she medicine Lygodium root. Methods The ethanol extract was isolated and purified by normal silica gel column chromatography and preparative high performance liquid chromatography, and its structure was identified by1H nuclear magnetic resonance spectroscopy,13C nuclear magnetic resonance and other techniques. Results Thirteen compounds were isolated and identified as: 6-hydroxy-2-isopropyl-7-methyl-1,4-naphthoquinone(1), protocatechuic aldehyde(2), vomifoliol(3),(E)-3, 4-dihydroxyphenylmethylene acetone(4), p-hydroxycinnamic acid(5), 3-chloro-4-hydroxy-benzoic acid(6), kaempfer-3-O-rutin glycoside(7),p-hydroxy benzaldehyde(8), daucosterol(9), 4-hydroxybenzylidenacetone(10), methyl 3, 4-dihydroxybenzoate(11),methyl gallate(12), 4-methoxy-6-(3’, 4’-dihydroxystyrene)-2-pyran(13). Conclusion 2-8 and 10-13 are the first compounds isolated from the genus Lygodium japonicum(Thunb.) Sw.

关 键 词：畲药 铜丝藤根 化学成分 分离 

分 类 号：R284[医药卫生—中药学]