哌拉西林钠他唑巴坦钠致大疱表皮松解型药疹一例  

A case of epidermolysis bullosa drug eruption caused by piperacillin sodium and tazobactam sodium

作　　者：农莉 苏棋 莫凯[1] 张慧玲[1] 秦艳娥[1] 蓝晓步 NONG Li;SU Qi;MO Kai(The First People’s Hosipital of Nanning,Nanning Guangxi 530022,China)

机构地区：[1]南宁市第一人民医院药学部,南宁532300

出　　处：《中国处方药》2022年第5期51-52,共2页Journal of China Prescription Drug

基　　金：2020年广西药品监督管理局局直属单位药品安全科研项目计划。

摘　　要：目的探讨患者发生大疱表皮松解型药疹的起因。方法梳理患者的诊疗经过,通过药物筛查、不良反应发生时间关联情况进行分析,探讨患者发生严重药品不良反应的原因。结果可疑药物包括泮托拉唑肠溶胶囊、哌拉西林钠他唑巴坦钠,经关联性评价对可疑药物的判断分别为“可能”、“很可能”。结论哌拉西林钠他唑巴坦钠致大疱表皮型松解型药疹属非常罕见,易被忽略,应引起临床重视。Objective To investigate the causes of epidermolysis bullosa drug eruption in patients.Methods The diagnosis and treatment process of the patients was sorted out,and the correlation between drug screening and adverse drug reaction time was analyzed to explore the causes of serious adverse drug reactions in patients.Results The suspicious drugs included pantoprazole enteric-coated capsules,piperacillin sodium and tazobactam sodium,which were judged as"possible"and"probable"respectively after correlation evaluation.Conclusion The epidermolysis of bullae caused by piperacillin sodium and tazobactam sodium is very rare,easy to be ignored,and should be paid attention to in clinic.

关 键 词：哌拉西林钠他唑巴坦钠 大疱表皮松解型药疹 药品不良反应 

分 类 号：R969[医药卫生—药理学]