阿奇霉素序贯治疗与左氧氟沙星序贯方案对社区获得性肺炎的疗效比较  

Efficacy Comparison of Azithromycin Sequential Treatment and Levofloxacin Sequential Regimen for Community-Acquired Pneumonia

作　　者：张树伟 Zhang Shu-wei(People's Hospital of Mengyin County,Linyi 276299,Shandong Province,China)

机构地区：[1]山东省蒙阴县人民医院,山东临沂276299

出　　处：《中国社区医师》2022年第14期10-12,共3页Chinese Community Doctors

摘　　要：目的:研究在社区获得性肺炎(CAP)治疗中,予以阿奇霉素及左氧氟沙星序贯方案干预的临床效果。方法:选取2019年1月-2021年12月蒙阴县人民医院收治的180例CAP患者为研究对象,依据随机数表形式分为两组,阿奇霉素序贯治疗的90例纳入对照组,左氧氟沙星序贯治疗的90例纳入观察组,对比两组治疗效果、肺功能指标、血气指标及不良反应发生率。结果:观察组治疗效果明显优于对照组,差异有统计学意义(P<0.05)。观察组肺功能指标均高于对照组,差异有统计学意义(P<0.05)。观察组pH值、动脉血氧分压高于对照组,动脉血二氧化碳分压低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在CAP治疗中,予以左氧氟沙星序贯方案较阿奇霉素序贯方案干预效果更显著,且安全性高,值得推广。Objective:To study the clinical effect of sequential intervention of azithromycin and levofloxacin in the treatment of community-acquired pneumonia(CAP).Methods:A total of 180 CAP patients admitted to People's Hospital of Mengyin County from January 2019 to December 2021 were selected as the study subjects,and were divided into 2 groups according to the random number table,90 patients who received azithromycin sequential therapy were included in the control group,and 90 patients who received levofloxacin sequential therapy were included in the observation group.The treatment effects,pulmonary function indexes,blood gas indexes,and incidence of adverse reactions were compared between the two groups.Results:The curative effect in the observation group was significantly better than that in the control group,and the difference was statistically significant(P<0.05).The pulmonary function indexes in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).The pH value and PaO2in the observation group were higher than those in the control group,and PaCO2 was lower than that in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between two group(P>0.05).Conclusion:The sequential regimen of levofloxacin has a more significant intervention effect than that of azithromycin,and it is safe and worthy of promotion.

关 键 词：阿奇霉素 左氧氟沙星 序贯方案 社区获得性肺炎 肺功能 

分 类 号：R563.1[医药卫生—呼吸系统]