基于贵金属纳米复合材料的表面增强拉曼散射活性基底的构建及其应用进展  

Fabrication and Application of Noble Metal Nanocomposites-Based Surface-Enhanced Raman Scattering Active Substrate

作　　者：林丙永 王悦靓 林振宇 郭隆华 LIN Bing-Yong;WANG Yue-Liang;LIN Zhen-Yu;GUO Long-Hua(Jiaxing Key Laboratory of Molecular Recognition and Sensing,College of Biological,Chemical Sciences and Engineering,Jiaxing University,Jiaxing 314001,China;Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety,Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology,College of Chemistry,Fuzhou University,Fuzhou 350116,China)

机构地区：[1]嘉兴学院生物与化学工程学院,嘉兴市分子识别材料与传感技术重点实验室,嘉兴314001 [2]福州大学化学学院,教育部食品安全与生物分析重点实验室,福建省食品安全分析与检测重点实验室,福州350116

出　　处：《分析化学》2022年第5期653-665,共13页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金项目(No.22074054);浙江省重点研发计划项目(No.2020C02022);浙江省自然科学基金项目(Nos.LQ20B050002,LQ20B050004);浙江省“万人计划”科技创新领军人才项目(No.2021R52044)资助。

摘　　要：表面增强拉曼散射(SERS)技术作为一种可快速、无损、超灵敏响应目标分子指纹信息的分析检测技术,广泛应用于食品检测、环境监测、临床诊断等领域。SERS技术在各领域实现超灵敏检测的关键环节是SERS基底的构建。目前,仅由单一贵金属纳米材料通过复杂耗时的方法构建的SERS基底的SERS活性、均匀性等难以满足各领域现场快速检测的需求。因此,越来越多的研究者致力于开发简单、快速构建多功能复合SERS基底的方法。本文主要对近年来贵金属纳米复合SERS基底的构建及其应用进展进行了综述,分析了不同贵金属纳米复合SERS基底的功能及优势,并对其未来的发展趋势进行了展望。With the rapid development of nanotechnology and laser technology,surface-enhanced Raman scattering(SERS)technology has flourished with a great leap.As an analysis and detection technology for fast,nondestructive,and ultra-sensitive response to the fingerprint information of the target molecule,SERS technology has been widely applied in the field of food detection,environmental monitoring and clinical diagnosis.Fabrication of SERS substrate is the committed step of achieving the ultra-sensitive detection in various fields using SERS technology.At present,the SERS activity,homogeneity,and other properties of SERS substrates which are constructed by single noble metal nanomaterials through complex and time-consuming methods cannot fit the demand of the point-of-care detection in various fields.Therefore,more and more research scholars focus on the development of simple and rapid methods to fabrication of multi-functional composite SERS substrates and application of these composite SERS substrates into the field of food detection,environmental monitoring and clinical diagnosis.This article mainly reviews the preparation of precious metal composite SERS substrates and their applications in the past years,discusses and analyzes the function and application advantages of multi-functional composite SERS substrates.The forecast of multi-functional composite SERS substrate is also provided at the end of this article.

关 键 词：复合表面增强拉曼散射基底 贵金属纳米粒子 复合材料 分析应用 评述 

分 类 号：O657.37[理学—分析化学] TB33[理学—化学]