槐果碱与β-环糊精及其衍生物的包合行为研究  

Study on Inclusion Behavior of Sophocarpine withβ-Cyclodextrin and Its Derivatives

作　　者：古捷 杨俊丽 鲁佳佳 高振杰 杨举 苏丽娇 陶欣 杨丽 杨丽娟 GU Jie;YANG Jun-li;LU Jia-jia;GAO Zhen-jie;YANG Ju;SU Li-Jiao;TAO Xin;YANG Li;YANG Li-Juan(Key Laboratory of Intelligent Supramolecular Chemistry at the University of Yunnan Province,National and Local Joint Engineering Research Center for Green Preparation Technology of Biobased Materials,School of Chemistry&Environment,Yunnan Minzu University,Kunming 650500,China)

机构地区：[1]云南民族大学化学与环境学院,云南省高校智能超分子化学重点实验室,生物基材料绿色制备技术国家地方联合工程中心,昆明650500

出　　处：《分析化学》2022年第5期781-790,I0017-I0019,共13页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金项目(No.21762051);云南省高校有机功能分子及材料科技创新团队项目;云南省教育厅科学研究基金项目(No.2020J0315)资助~~

摘　　要：以槐果碱(SOP)为客体,β-环糊精(β-CD)、羟丙基-β-环糊精(HP-β-CD)、三甲基-β-环糊精(TM-β-CD)、单-(6-乙二胺基-6-去氧)-β-环糊精(2N-β-CD)和单-(6-二乙烯三胺-6-去氧)-β-环糊精(3N-β-CD)为主体,采用饱和溶液法制备了5种主-客体包合物。通过一维和二维核磁共振(^(1)H NMR、2D NMR)、紫外-可见吸收光谱(UV-Vis)、X-射线粉末衍射(XRD)和扫描电镜(SEM)等分析方法对主-客体包合物进行了表征。结果表明,SOP与5种环糊精的主-客体包合比均为1∶1;包合物形成后,SOP的水溶性和稳定性均明显提高,并且包合物在酸性条件下更稳定。核磁共振分析结果表明,SOP的D环从CDs的小口端进入其空腔,而SOP的C环则贯穿在CDs的空腔内。By using sophocarpine(SOP) as the guest, and β-cyclodextrin(β-CD), hydroxypropyl-β-cyclodextrin(HP-β-CD), trimethyl-β-cyclodextrin(TM-β-CD), mono-(6-ethanediamine-6-deoxy)-β-cyclodextrin(2 N-β-CD) and mono-(6-diethylenetriamine-6-deoxy)-β-cyclodextrin(3 N-β-CD) as the host, five host-guest inclusions were prepared by the saturated solution method. The host-guest inclusion complexes were characterized by one-dimensional and two-dimensional nuclear magnetic resonance(~1H NMR, 2 D NMR), ultraviolet-visible spectroscopy(UV-Vis), X-ray powder diffraction(XRD) and scanning electron microscopy(SEM). The results showed that the host-guest inclusion ratios of the SOP to the five cyclodextrins were all 1∶1. After the formation of inclusion complexes, the water solubility and stability of SOP were obviously increased, and the inclusion compounds were more stable under acidic conditions. Nuclear magnetic resonance analysis showed that the D ring of SOP entered its cavity from the narrow side of the CDs, while the C ring of SOP penetrated the cavity of CDs.

关 键 词：槐果碱 Β-环糊精及其衍生物 包合行为 溶解度 稳定性 

分 类 号：TQ460.1[化学工程—制药化工]