中性粒细胞胞外捕获网防御机制的研究进展  

Research progress on defense mechanism of neutrophil extracellular traps

作　　者：谢何昕 鲁文赓[1] 司琳清 袁思琦 周继伟 姚旭东 Xie Hexin;Lu Wengeng;Si Linqing;Yuan Siqi;Zhou Jiwei;Yao Xudong(College of Animal Science and Veterinary Medicine,Heilongjiang Bayi Agricultural University,Heilongjiang Daqing 163319)

机构地区：[1]黑龙江八一农垦大学动物科技学院,黑龙江大庆163319

出　　处：《现代畜牧兽医》2022年第4期93-96,共4页Modern Journal of Animal Husbandry and Veterinary Medicine

基　　金：黑龙江八一农垦大学研究生创新科研资助项目(YJSCX2021-Y15)。

摘　　要：中性粒细胞作为先天免疫的吞噬细胞,在免疫防御中起核心作用。中性粒细胞胞外捕获网(NETs)的发现使中性粒细胞再次成为研究热点。NETs通过其内含的抗菌肽和诸多的酶系统进行捕获、抑制和杀灭病原微生物。NETs参与炎症和多种自身免疫调节疾病的发生发展。文章就NETs的形成机制以及NETs的宿主防御作用展开综述,以期为相关研究及应用提供参考。As innate immune phagocytes,neutrophils play a important role in immune defense.The discovery of neutrophil extracellular traps(NETs)makes neutrophils becoming a hot topics again.NETs can capture,inhibit and kill pathogenic microorganisms through its antibacterial peptides and many enzyme systems.Many studies have found that NETs are involved in the occurrence and development of inflammation and a variety of autoimmune diseases.The article reviews the formation mechanism of NETs and the host defense role of NETs,in order to provide reference for related research and application.

关 键 词：中性粒细胞 防御机制 中性粒细胞胞外捕获网 

分 类 号：S852[农业科学—基础兽医学]