MRI-DTI联合DKI检查在帕金森病诊断中的效能  

Efficacy of MRI-DTI combined with DKI in diagnosis of Parkinson’s disease

作　　者：刘广辉 LIU Guanghui(Department of Medical Imaging of Ningling County People’s Hospital,Shangqiu 476700 Henan,China)

机构地区：[1]宁陵县人民医院医学影像部,河南商丘476700

出　　处：《中国民康医学》2022年第9期119-122,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨磁共振成像(MRI)-弥散张量成像(DTI)联合扩散峰度成像(DKI)检查在帕金森病(PD)诊断中的效能。方法:回顾性分析2020年1月至2021年1月本院收治的60例PD患者的临床资料,设为PD组,另选取同期收治的60例原发性震颤患者设为非PD组。两组均行DTI、DKI检查,比较DTI检查中黑质各向异性分数(FA)值、DKI检查中黑质平均扩散峰度(MK)值单项及联合诊断PD的效能。结果:在黑质中,DTI检查PD组FA值小于非PD组,差异有统计学意义(P<0.05);在红核、下丘脑中,DTI检查两组FA值比较,差异无统计学意义(P>0.05);在黑质、红核、下丘脑中,DTI检查两组表观扩散系数(ADC)值比较,差异均无统计学意义(P>0.05);在黑质、红核、下丘脑中,DKI检查两组FA值比较,差异均无统计学意义(P>0.05);在黑质中,DKI检查PD组MK值大于非PD组,差异有统计学意义(P<0.05);在红核、下丘脑中,DKI检查两组MK值比较,差异无统计学意义(P>0.05);受试者工作曲线(ROC)分析结果显示,DTI检查中黑质FA值、DKI检查中黑质MK值单项及联合评估PD的曲线下面积(AUC)分别为0.812、0.846、0.900,且黑质中FA值、MK值的Cut-off值分别为0.535、0.775时,可获得最佳诊断价值,而两个指标联合检查诊断价值更高(P<0.05)。结论:DTI检查中黑质FA值、DKI检查中黑质MK值联合诊断PD的效能高于两者单项检查诊断。Objective:To investigate efficacy of magnetic resonance imaging(MRI)-diffusion tensor imaging(DTI)combined with diffusion kurtosis imaging(DKI)in diagnosis of Parkinson’s disease(PD).Methods:The clinical data of 60 PD patients admitted to our hospital from January 2020 to January 2021 were retrospectively analyzed and set as PD group,while the 60 patients with essential tremor during the same period were selected as non-PD group.Both groups underwent DTI and DKI examinations.The efficacies of fractional anisotropy(FA)value of substantia nigra in DTI examination,the mean diffusion kurtosis(MK)value of substantia nigra in DKI examination,and the combined examination in the diagnosis of PD were compared.Results:In the substantia nigra,the FA value of the PD group was smaller than that of the non-PD group,and the difference was statistically significant(P<0.05).In the red nucleus and hypothalamus,there were no significant differences in the FA value between the two groups(P>0.05).In the substantia nigra,red nucleus,and hypothalamus,there was no significant difference in the apparent diffusion coefficient(ADC)value between the two groups(P>0.05).In the substantia nigra,red nucleus and hypothalamus,there was no significant difference in the FA value between the two groups(P>0.05).In the substantia nigra,the MK value of the PD group was greater than that of the non-PD group,and the difference was statistically significant(P<0.05).In the red nucleus and hypothalamus,there was no significant difference in the MK value between the two groups(P>0.05).The receiver operating curve(ROC)results showed that the areas under the curve(AUC)of the substantia nigra FA value in DTI examination,the substantia nigra MK value in DKI examination and the combined examination in the diagnosis of PD were 0.812,0.846,and 0.900,separately.The best diagnostic value can be obtained when the Cut-off values of FA and MK values in the substantia nigra were 0.535 and 0.775,respectively.The combined examination of the two indicators had higher diag

关 键 词：帕金森病 磁共振成像 弥散张量成像 扩散峰度成像 检查 诊断 效能 

分 类 号：R445[医药卫生—影像医学与核医学] R742[医药卫生—诊断学]