疏风通络方治疗支气管哮喘急性发作期风痰阻肺证的临床疗效及对IL-6、IL-8、IFN-γ的影响  

Observation of the Clinical Efficacy of Wind-Dispersing and Meridian-Dredging Decoction in the Treatment of Wind-Phlegm Blocking Lung Syndrome in Acute Attack of Bronchial Asthma

作　　者：钟新春[1,2] 朱振刚 刘超武[1,2] ZHONG Xin-chun;ZHU Zhen-gang;LIU Chao-wu(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin,China,300381;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin,China,300381)

机构地区：[1]天津中医药大学第一附属医院,天津300381 [2]国家中医针灸临床医学研究中心,天津300381

出　　处：《河南中医》2022年第7期1052-1055,共4页Henan Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81673900)。

摘　　要：目的:观察疏风通络方治疗支气管哮喘风痰阻肺证的临床疗效及对血清白细胞介素-6(interleukin-6,IL-6)、IL-8、γ-干扰素(interferon-γ,IFN-γ)的影响。方法:选取天津中医药大学第一附属医院2019年6月至2021年7月治疗的支气管哮喘急性发作期风痰阻肺证患者为研究对象,共128例,按照随机数字表法分为对照组和观察组各64例。对照组采用雾化吸入布地奈德混悬液、硫酸特布他林治疗,观察组在对照组治疗的基础上采用疏风通络方治疗,两组患者均连续治疗7 d。比较两组患者临床疗效和治疗前后中医证候积分、哮喘控制情况、肺功能、血清IL-6、IL-8、IFN-γ水平。结果:对照组有效率为64.06%,观察组有效率为89.06%,两组有效率比较,差异有统计学意义(P<0.05)。两组患者治疗后中医证候积分和哮喘控制测试(asthma control test,ACT)评分均降低,且观察组低于对照组,差异有统计学意义(P<0.05)。两组患者治疗后第1秒用力呼气容积(forced expiratory volume in the first second,FEV_(1))、呼气流量峰值(peak expiratory flow,PEF)升高,用力肺活量(forced vital capacity,FVC)降低,且组间比较,差异有统计学意义(P<0.05)。两组患者治疗后血清IL-6、IL-8、IFN-γ水平均降低,且组间比较,差异有统计学意义(P<0.05)。结论:疏风通络方治疗支气管哮喘急性发作期风痰阻肺证,可有效改善哮喘症状,改善肺功能,其机制可能与降低血清IL-6、IL-8、IFN-γ表达有关。Objective:To observe the clinical efficacy of Wind-Dispersing and Meridian-Dredging Decoction on wind-phlegm blocking lung syndrome of bronchial asthma and its effect on serum interleukin-6(IL-6),interleukin-8(IL-8)andγ-interferon.Methods:A total of 128 patients with acute attack of asthma and TCM wind-phlegm blocking lung syndrome treated in First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from June 2019 to July 2021 were selected as the research subjects.They were randomly divided into the control group and observation group,with 64 cases in each group.The control group was treated with aerosol inhalation of budesonide suspension and terbutaline sulfate.The observation group was treated with Wind-Dispersing and Meridian-Dredging Decoction on the basis of the treatment of the control group.The patients in both groups were treated for 7 days.The clinical efficacy,TCM syndrome score,asthma control,pulmonary function,serum IL-6,IL-8 and IFN-γlevels were compared between the two groups before and after treatment.Results:The effective rate was 64.06%in the control group and 89.06%in the observation group,and there was significant difference between the two groups(P<0.05).After treatment,the TCM syndrome score and asthma control test(ACT)score of the two groups decreased,and the above indexes of the treatment group were lower than those of the control group,and all the difference was statistically significant(P<0.05).The forced expiratory volume in the first second(FEV_(1)),peak expiratory flow(PEF)and forced vital capacity(FVC)of the two groups increased after treatment,and all the differences between the two groups were statistically significant(P<0.05).The levels of serum IL-6,IL-8 and IFN-γin the two groups decreased after treatment,and all the differences between the two groups were statistically significant(P<0.05).Conclusion:Wind-Dispersing and Meridian-Dredging Decoction can effectively improve asthma symptoms and pulmonary function in the treatment of wind-phlegm blocking lung

关 键 词：支气管哮喘 风痰阻肺证 疏风通络方 肺功能 白细胞介素-6 白细胞介素-8 Γ-干扰素 中西医结合疗法 

分 类 号：R259.622.5[医药卫生—中西医结合]