肠道复苏联合大承气汤在危重症患者肠道功能恢复中的应用  

Application of intestinal resuscitation combined with Dachengqi decoction in intestinal function recovery of critically ill patients

作　　者：郑红情[1] 张文源[1] 张阿利[1] 林荣海[1] ZHENG Hongqing;ZHANG Wenyuan;ZHANG Ali;LIN Ronghai(Department of Critical Care Medicine,Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University,Linhai 317000,China)

机构地区：[1]浙江省台州医院重症医学科,浙江临海317000

出　　处：《中国现代医生》2022年第15期69-71,99,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2019ZH062)。

摘　　要：目的 探讨肠道复苏联合大承气汤在危重症患者肠道功能恢复中的作用。方法 选择2019年1月至2020年3月浙江省台州医院收治的危重症患者60例,随机分为观察组与对照组,每组各30例。对照组给予常规肠道复苏,观察组在此基础上加用大承气汤治疗。比较两组治疗前后的肠功能评分,PCT、CRP、TNF-α、IL-1、IL-6水平及治疗过程中的不良反应发生率。结果 (1)治疗后,两组的肠功能评分较治疗前显著下降,差异有统计学意义(P<0.05);观察组的肠功能评分均低于对照组,差异有统计学意义(P<0.05)。(2)治疗后,两组的PCT、CRP、TNF-α、IL-1、IL-6水平均较治疗前下降,差异有统计学意义(P<0.05);治疗后,观察组的PCT、CRP、TNF-α、IL-1、IL-6显著低于对照组,差异有统计学意义(P<0.05)。(3)观察组的并发症总发生率低于对照组,差异有统计学意义(P<0.05)。结论 肠道复苏联合大承气汤可促进危重症患者的肠道功能恢复,降低炎症因子指标。Objective To investigate the effect of intestinal resuscitation combined with Dachengqi decoction in intestinal function recovery of critically ill patients.Methods A total of 60 critically ill patients who were diagnosed and treated in Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University from January 2019 to March 2020 were selected as the research objects,and randomly divided into the observation group and the control group,with 30 patients in each group.The control group was given routine intestinal resuscitation,and the observation group was treated with Dachengqi decoction on the basis of the control group.The intestinal function scores,PCT,CRP,TNF-α,IL-1,and IL-6 levels,and the incidences of adverse reactions during treatment were compared between the two groups before and after treatment.Results①After treatment,the intestinal function scores of the two groups were decreased significantly compared with those before treatment,and the differences were statistically significant(P<0.05).And the intestinal function scores of the observation group were lower than those of the control group,with statistically significant differences(P<0.05).②After treatment,PCT,CRP,TNF-α,IL-1 and IL-6 in the 2 groups were decreased compared with those before treatment,the differences were statistically significant(P<0.05).After treatment,PCT,CRP,TNF-α,IL-1 and IL-6 in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).③The total incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The intestinal resuscitation combined with Dachengqi decoction can promote the recovery of intestinal function in critically ill patients,reduce inflammatory factors.

关 键 词：肠道复苏 大承气汤 危重症 肠道功能 

分 类 号：R289.5[医药卫生—方剂学]