宫颈鳞状细胞癌组织中长链非编码RNA肿瘤蛋白P73反义链1的表达及其与预后的关系  

Expression of lncRNA TP73-AS1 in cervical squamous cell carcinoma and its relationship with prognosis

作　　者：庞晓庆 周永江 张春雨 PANG Xiaoqing;ZHOU Yongjiang;ZHANG Chunyu(Department of Gynacology,Hainan Women and Children's Medicine Center,Haikou 570206,Hainan,China;Teaching and Research Section of Matemal,Child and Adolescent Health,Hainan Medical College,Haikou 571100,Hainan,China;Department of Pregmancy and Health Care,Hainan Women and Children's Medicine Center,Haikou 570206,Hainan,China)

机构地区：[1]海南省妇女儿童医学中心妇科,海口570206 [2]海南医学院儿少与妇幼保健学教研室,海口571100 [3]海南省妇女儿童医学中心孕产保健科,海口570206

出　　处：《中国性科学》2022年第5期88-92,共5页Chinese Journal of Human Sexuality

基　　金：海南省自然科学基金项目(20158277)。

摘　　要：目的探讨宫颈鳞状细胞癌(CSCC)组织中长链非编码RNA肿瘤蛋白P73反义链1(lncRNA TP73-AS1)的表达及其与预后的关系。方法选取海南省妇女儿童医学中心2017年1月至2018年3月收治的93例CSCC患者作为研究对象。采用实时荧光定量聚合酶链反应(qRT-PCR)法检测其CSCC组织和癌旁组织中lncRNA TP73-AS1的表达;分析lncRNA TP73-AS1的表达与CSCC患者临床病理特征的关系;采用Kaplan-Meier曲线绘制不同lncRNA TP73-AS1表达水平CSCC患者术后3年的生存曲线;采用Cox回归分析CSCC患者预后不良的影响因素。结果CSCC组织中lncRNA TP73-AS1的表达明显高于癌旁组织,且与CSCC患者国际妇产科联盟(FIGO)分期、淋巴结转移相关(P<0.05);lncRNA TP73-AS1高表达患者术后3年总生存率明显低于lncRNA TP73-AS1低表达患者(P<0.05);FIGO分期Ⅲ~Ⅳ期(HR=2.528,95%CI:1.080~4.914)、有淋巴结转移(HR=3.713,95%CI:2.336~5.316)、lncRNA TP73-AS1表达≥2.128(HR=2.730,95%CI:1.157~4.444)为CSCC患者预后不良的独立风险因素(P<0.05)。结论CSCC组织中lncRNA TP73-AS1表达上调,与患者的FIGO分期和淋巴结转移情况相关,且其为患者预后不良的独立风险因素,可能成为CSCC治疗的新靶点。Objective To investigate the expression of long non-coding RNA tumor protein P73 antisense strand 1(lncRNA TP73-AS1)in cervical squamous cell carcinoma(CSCC)and its relationship with prognosis.Methods A total of 93 patients with CSCC admitted to Hainan Women and Children′s Medicine Center from January 2017 to March 2018 were selected.The expression of lncRNA TP73-AS1 in CSCC and adjacent tissues was detected by real-time fluorescence quantitative polymerase chain reaction(qRT-PCR);the relationship between the expression of lncRNA TP73-AS1 in CSCC and the clinicopathological features of CSCC patients was analyzed;Kaplan-Meier curve was used to draw the 3-year survival curve of CSCC patients with different lncRNA TP73-AS1 in CSCC expression levels;Cox regression was used to analyze the influencing factors of poor prognosis in CSCC patients.Results The expression of lncRNA TP73-AS1 in CSCC tissue was significantly higher than that in adjacent tissues,which was related to the stage of the federation international of gynecology and obstetrics(FIGO)and lymph node metastasis in CSCC patients(P<0.05).The 3-year overall survival rate of patients with high lncRNA TP73-AS1 expression was significantly lower than that of patients with low lncRNA TP73-AS1 expression(P<0.05).FIGO stageⅢtoⅣ(HR=2.528,95%CI:1.080-4.914),lymph node metastasis(HR=3.713,95%CI:2.336-5.316),lncRNA TP73-AS1≥2.128(HR=2.730,95%CI:1.157-4.444)were independent risk factors for poor prognosis of CSCC patients(P<0.05).Conclusions The expression of lncRNA TP73-AS1 in CSCC tissues is up-regulated,which is related to FIGO stage and lymph node metastasis.It is an independent risk factor for poor prognosis and may become a new therapeutic target for CSCC.

关 键 词：宫颈鳞状细胞癌 长链非编码RNA肿瘤蛋白P73反义链1 预后 

分 类 号：R711[医药卫生—妇产科学]