盐酸布桂嗪超前镇痛在经皮椎体成形手术中的应用  

Application of preemptive analgesia with bucinnazine hydrochloride in percutaneous vertebro plasty

作　　者：肖明玉 XIAO Mingyu(Laizhou Hospital of Traditional Chinese Medicine in Shandong Province,Yantai 261400,China)

机构地区：[1]山东省莱州市中医医院,山东烟台261400

出　　处：《中国现代医生》2022年第14期125-128,共4页China Modern Doctor

摘　　要：目的研究盐酸布桂嗪的超前镇痛在椎体成形手术中的镇痛效果及安全性。方法选取2020年1—12月山东省莱州市中医医院收治入院行椎体成形(PVP)局麻手术的患者60例,随机分为超前镇痛组和对照组,每组各30例,超前镇痛组给盐酸布桂嗪100 mg术前30 min皮下注射,对照组给予等量生理盐水皮下注射。记录患者在注射药物前、穿刺过程中、骨水泥推注过程中和手术结束转平卧位时的疼痛评分(VAS)、平均动脉压、心率及不良反应。结果注射药物前,两组患者的疼痛评分、平均动脉压、心率无统计学差异(P>0.05);穿刺及骨水泥推注过程中超前镇痛组的VAS评分分别为(3.77±0.97)分、(4.87±1.34)分,对照组分别为(4.33±0.99)分、(5.77±1.10)分,超前镇痛组低于对照组,差异有统计学意义(P<0.05),手术结束转平卧位时,两组患者的VAS评分差异无统计学意义(P>0.05),考虑可能与骨水泥硬化后,脊柱稳定性增加有关;在穿刺、骨水泥推注过程中和手术结束转平卧位时,超前镇痛组的平均动脉压、心率均低于对照组,差异有统计学意义(P<0.05),超前镇痛组未出现恶心等不良反应,对照组出现2例轻度恶心。结论盐酸布桂嗪用于局麻下椎体成形术,能够有效缓解术中疼痛,减少不良反应的发生。Objective To study the analgesic effect and safety of preemptive analgesia with bucinnazine hydrochloride in percutaneous vertebro plasty(PVP).Methods A total of 60 patients admitted to Laizhou Hospital of Traditional Chinese Medicine in Shandong Province for PVP surgery under local anesthesia from January to December 2020 were selected and randomly divided into the preemptive analgesia group and the control group,with 30 patients in each group.The preemptive analgesia group was subcutaneously injected with 100 mg of bucinnazine hydrochloride 30 minutes before surgery,while the control group was subcutaneously injected with equal amount of normal saline.The pain scores(Visual Analogue Scale[VAS]scores),mean arterial pressure,heart rate and adverse reactions of patients were recorded before drug injection,during puncture,during bone cement injection and when they changed their position to the supine position at the end of surgery.Results Before drug injection,there were no statistical differences between the two groups in VAS scores,mean arterial pressure and heart rate(P>0.05).The VAS scores were respectively(3.77±0.97)points and(4.87±1.34)points in the preemptive analgesia group,and(4.33±0.99)points and(5.77±1.10)points in the control group during puncture and bone cement injection,and those in the preemptive analgesia group were lower than those in the control group,with statistical differences(P<0.05).There was no statistical difference between the two groups in VAS scores when the patients changed their position to the supine position at the end of surgery(P>0.05),which might be related to the increased spinal stability after bone cement hardening.The mean arterial pressure and heart rate in the preemptive analgesia group were lower than those in the control group during puncture,during bone cement injection and when the patients changed their position to the supine position at the end of surgery,with statistical differences(P<0.05).There were no adverse reactions such as nausea in the preemptive analgesi

关 键 词：盐酸布桂嗪 超前镇痛 椎体成形 疼痛评分 

分 类 号：R614.3[医药卫生—麻醉学]