circRNA及其在畜禽遗传调控中的研究进展  

Research Progress on circ RNA and Genetic Regulation of Livestock and Poultry

作　　者：戎友俊 尚方正 马荣 王敏[1,2,3,4] 潘剑锋 梁丽丽 张燕军 李金泉[1,2,3,4] RONG Youjun;SHANG Fangzheng;MA Rong;WANG Min;PAN Jianfeng;LIANG Lili;ZHANG Yanjun;LI Jinquan(College of Animal Science,Inner Mongolia Agricultural University,Inner Mongolia Hohhot 010018,China;Key Laboratory of Mutton Sheep Genetics and Breeding,Ministry of Agriculture,Inner Mongolia Hohhot 010018,China;Key Laboratory of Animal Genetics,Breeding and Reproduction,Inner Mongolia Autonomous Region,Inner Mongolia Hohhot,010018,China;Engineering Research Center for Goat Genetics and Breeding,Inner Mongolia Autonomous Region,Inner Mongolia Hohhot 010018,China)

机构地区：[1]内蒙古农业大学动物科学学院,内蒙古呼和浩特010018 [2]农业农村部肉羊遗传育种重点实验室,内蒙古呼和浩特010018 [3]内蒙古自治区动物遗传育种与繁殖重点实验室,内蒙古呼和浩特010018 [4]内蒙古自治区山羊遗传育种工程技术研究中心,内蒙古呼和浩特010018

出　　处：《中国畜牧杂志》2022年第5期82-90,共9页Chinese Journal of Animal Science

基　　金：国家自然科学基金项目(31860627);内蒙古自治区科技计划项目(2019GG243)。

摘　　要：环状RNA(Circular RNAs,circRNAs)是一种新型的内源性非编码RNA,由mRNA前体反向剪接形成共价闭环结构。circRNA没有5’端帽子和3’端多聚腺苷酸尾巴,广泛表达于各种组织中。受技术限制,早期普遍认为circRNA是错误剪接的产物,但随着高通量测序技术的迅速发展和广泛使用,circRNA又重新回到研究前沿,同时越来越多的circRNA在各个物种中被鉴定。本文综述了circRNA的产生、特征、性质、功能及其在畜禽遗传调控中的应用研究,以期为探究circRNA在畜禽生产中的功能机制提供理论依据。circular RNAs(circular RNAs,circRNAs)is a new type of endogenous non-coding RNA,which is formed by backsplicing of mRNA precursors to form a covalent closed loop structure.circRNAs has no 5’-end cap and 3’-end polyadenylic acid tail,and it is widely expressed in various tissues.Due to technical limitations,people believed that circRNAs was the product of missplicing.With the rapid development and widespread use of high-throughput sequencing technology,circRNAs has returned to the forefront of research.At the same time,more and more circRNAs is identified in various species.Therefore,this article reviews the production,characteristics,properties,functions of circRNA and its application in genetic regulation of livestock and poultry,hoping to provide a theoretical basis for exploring the functional mechanism of circRNA in livestock and poultry production.

关 键 词：circRNA 机制 生物学功能 畜禽遗传调控 应用研究 

分 类 号：S813.1[农业科学—畜牧学]