哌拉西林钠他唑巴坦钠致多发伤患者发热并急性肝损伤1例  

One case of multiple injuries with fever and acute liver injury caused by piperacillin sodium and tazobactam sodium

作　　者：李瑞[1] 王瑞洁 孙斌[1] 张洪光 袁莹 邱建清[1] Li Rui;Wang Ruijie;Sun Bin;Zhang Hongguang;Yuan Ying;Qiu Jianqing(Emergency Department,Affiliated Hospital of Binzhou Medical University,Binzhou 256600,China;Department of Internal Medicine,Binzhou Hospital of Traditional Chinese Medicine,Binzhou 256600,China)

机构地区：[1]滨州医学院附属医院急诊科,滨州256600 [2]滨州市中医医院内科,滨州256600

出　　处：《国际医药卫生导报》2022年第11期1595-1597,共3页International Medicine and Health Guidance News

摘　　要：哌拉西林是一种广谱青霉素类抗生素,当与β-内酰胺酶抑制剂他唑巴坦联用时用于治疗敏感菌所致的中度至重度感染性疾病,常见的不良反应有过敏、皮疹、胃肠道反应等,亦可致发热并药物性肝损伤,但导致发热并急性肝损伤的病例罕见。本文报道1例患者应用哌拉西林钠他唑巴坦钠时出现的发热并急性肝损伤的病例,目的是能引起临床医生的关注,并为早发现、早诊断、早干预提供参考。Piperacillin is a broad-spectrum penicillin antibiotic.It is used in combination withβ-lactamase inhibitor tazobactam for moderate to severe infectious diseases caused by sensitive bacteria.Its common adverse reactions include allergy,rash,gastrointestinal reactions,etc.,and can also lead to fever and drug-induced liver injury,but cases resulted in fever and acute liver injury are rare.This paper reports the fever and acute liver injury in a patient who was treated with piperacillin sodium and tazobactam sodium.The purpose is to arouse the attention of clinicians,and to provide references for early detection,diagnosis,and intervention.

关 键 词：哌拉西林钠他唑巴坦钠 药物性肝损伤 药品不良反应 

分 类 号：R969.3[医药卫生—药理学]