胃食管反流病对慢性阻塞性肺疾病患者生活质量及肺功能的影响  

Effect of gastroesophageal reflux disease on quality of life and pulmonary function in patients with chronic obstructive pulmonary disease

作　　者：李瑛[1] 陈张琴[1] LI Ying;CHEN Zhangqin(Department of Respiratory and Critical Care Medicine,Second People's Hospital of Shaanxi Province,Xi'an 710005,China)

机构地区：[1]陕西省第二人民医院呼吸与危重症医学科,陕西西安710005

出　　处：《陕西医学杂志》2022年第6期702-705,共4页Shaanxi Medical Journal

基　　金：陕西省卫生和计划生育委员会科研项目(2016D084)。

摘　　要：目的:探讨胃食管反流病(GERD)对慢性阻塞性肺疾病(COPD)患者生活质量及肺功能的影响。方法:纳入COPD急性加重(AECOPD)患者120例为研究对象。所有患者均进行胃食管反流病问卷(GerdQ)调查,按照是否合并GERD为GERD组(57例,GerdQ评分≥8分)和非GERD组(63例,GerdQ评分<8分)。记录两组患者的一般资料。待患者进入稳定期后,对所有患者进行圣乔治呼吸问卷(SGRQ)调查和肺功能指标[第一秒用力呼气容积(FEV_(1))、FEV_(1)与用力肺活量(FVC)比值以及第一秒用力呼气容积占预计值百分比(FEV_(1)%pred)]检测。比较两组患者SGRQ问卷中症状、活动能力、疾病影响评分及总评分。比较两组患者FEV_(1)、FEV_(1)/FVC、FEV_(1)%pred以及AECOPD发作次数。结果:GERD组SGRQ问卷中症状、活动能力、疾病影响单项评分及总评分高于非GERD组(均P<0.05)。GERD组FEV_(1)、FEV_(1)/FVC及FEV_(1)%pred低于非GERD组(均P<0.05)。GERD组AECOPD发作次数多于非GERD组(P<0.05)。结论:与不合并GERD的COPD患者相比,合并GERD的COPD患者生活质量更低,肺功能更差,急性发作次数更多。Objective:To investigate the effect of gastroesophageal reflux disease(GERD)on quality of life and pulmonary function in patients with chronic obstructive pulmonary disease(COPD).Methods:A total of 120 patients with acute exacerbation of COPD(AECOPD)were included.All patients were investigated with GerdQ and were divided into GERD group(57 cases,GerdQ score≥8)and non-GERD group(63 cases,GerdQ score<8)according to whether GERD was combined.General data of both groups of patients were recorded.After the patients entered the stable phase,the SGRQ and pulmonary function indexes(FEV_(1),FEV_(1)/FVC,and FEV_(1)%pred)measurements were performed on all patients.The score of symptoms,activity ability,disease influence and total score in the SGRQ were compared between the two groups.FEV_(1),FEV_(1)/FVC,FEV_(1)%pred and the number of AECOPD episode were compared between the two groups.Results:The scores of symptom,activity ability,disease influence and total scores in the SGRQ of GERD group were higher than those of non-GERD group(all P<0.05).The FEV_(1),FEV_(1)/FVC,and FEV_(1)%pred in the GERD group were lower than those in the non-GERD group(all P<0.05).The number of AECOPD episode was higher in the GERD group than that in the non-GERD group(P<0.05).Conclusion:Compared with COPD patients without GERD,COPD patients with GERD had lower quality of life,worse pulmonary function,and more exacerbations.

关 键 词：慢性阻塞性肺疾病 胃食管反流病 胃食管反流问卷 圣乔治呼吸问卷 肺功能 生活质量 

分 类 号：R563.9[医药卫生—呼吸系统]