抗生素降阶梯方案治疗老年重症肺炎患者的临床效果  

Clinical Effect of Elderly Patients with Severe Pneumonia with Antibiotic Descending Ladder Scheme

作　　者：王春晓 WANG Chunxiao(Department of Emergency,Kuandian County Central Hospital,Dandong 118200,China)

机构地区：[1]宽甸县中心医院急诊科,辽宁丹东118200

出　　处：《中国医药指南》2022年第14期9-12,共4页Guide of China Medicine

摘　　要：目的评价老年重症肺炎患者行抗生素降阶梯方案治疗的可行性,为老年重症肺炎患者临床治疗工作提供参考,确保治疗效果与患者安全性。方法选择我院2018年6月至2019年8月收治住院治疗的80例老年重症肺炎患者。结合治疗方法对80例老年重症肺炎患者进行1∶1配比法分组,对照组、试验组各40例。对照组患者行常规抗生素治疗,试验组患者行抗生素降阶梯方案治疗。对比两组患者治疗后的临床效果、肺功能水平以及抗生素使用时间、咳嗽消失时间、退热时间、总住院治疗时间。结果观察组患者经治疗后总有效率(97.50%vs.77.50%)显著优于对照组,P<0.05。观察组的FEV1[(2.75±0.30)L vs.(1.66±0.33)L]显著优于对照组,FVC[(3.25±0.55)L vs.(2.63±0.58)L]显著优于对照组,使用抗生素时间[(11.50±1.20)d vs.(19.20±1.50)d]显著短于对照组,咳嗽消失时间[(9.50±1.50)d vs(.13.50±2.50)d]显著短于对照组,退热时间[(10.50±1.00)d vs.(14.50±1.50)d]显著短于对照组,住院时间[(16.50±1.00)d vs.(20.00±1.30)d]显著短于对照组,差异均有统计学意义,P均<0.05。结论对比常规抗生素治疗,使用抗生素降阶梯方案治疗老年重症肺炎患者的效果更佳,可促进症状体征改善、缩短治疗时间,是优选治疗方案。Objective To evaluate the feasibility of antibiotic ladder down treatment for the elderly patients with severe pneumonia,and to provide reference for the clinical treatment of the elderly patients with severe pneumonia,so as to ensure the treatment effect and patient safety.Methods From June 2018 to August 2019,80 elderly patients with severe pneumonia were admitted to our hospital.Combined with the treatment,80 elderly patients with severe pneumonia were divided into 1∶1 proportion group,the control group and the experimental group,40 cases in each group.The control group were treated with routine antibiotics,and the experimental group were treated with antibiotic ladder down scheme.To compare the clinical effect,lung function index,antibiotic administration time,cough disappearance time,antipyretic time and hospitalization time between the control group and the experimental group.Results The total clinical effective rate(97.50%vs.77.50%)of the observation group was significantly higher than that of the control group,P<0.05.The FEV1[(2.75±0.30)L vs.(1.66±0.33)L]of the observation group was significantly higher than that of the control group,and the FVC[(3.25±0.55)L vs.(2.63±0.58)L]was significantly higher than that of the control group.[(11.50±1.20)d vs.(19.20±1.50)d]was significantly shorter than that of the control group,and the cough disappearance time[(9.50±1.50)d vs.(13.50±2.50)d]was significantly shorter than that of the control group,and the fever reduction time[(10.50±1.00)d vs.(14.50±1.50)d]was significantly shorter than the control group,and the length of hospital stay[(16.50±1.00)d vs.(20.0±1.3)d]was significantly shorter than the control group,the differences were statistically significant,P All<0.05.Conclusion Compared with conventional antibiotic treatment,the use of antibiotic de-escalation regimen in the treatment of elderly patients with severe pneumonia is more effective,can promote the improvement of symptoms and signs,and shorten the treatment time,which is the preferred treatme

关 键 词：重症肺炎 老年 抗生素降阶梯方案 药物治疗 

分 类 号：R563.1[医药卫生—呼吸系统]