长春瑞滨药动学及毒副作用研究进展  

Research progress on pharmacokinetics and toxicity of vinorelbine

作　　者：刘花 陈延绅 尤慧柠 冯燕 李敏[1] 寇建蓉 魏俊松 封卫毅[1] LIU Hua;CHEN Yanshen;YOU Huining;FENG Yan;LI Min;KOU Jianrong;WEI Junsong;FENG Weiyi(Dept.of Pharmacy,the First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,China)

机构地区：[1]西安交通大学第一附属医院药学部,西安710061

出　　处：《中国药房》2022年第11期1403-1408,共6页China Pharmacy

基　　金：国家自然科学基金资助项目(No.81972814)。

摘　　要：长春瑞滨(NVB)是一种半合成的长春花生物碱,可通过抑制微管蛋白的合成而发挥抗肿瘤作用,因其口服制剂服用方便且具有良好的临床疗效,目前已应用于多种肿瘤的治疗。NVB血药浓度与其疗效及毒副作用密切相关,血药浓度较小的变化即有可能降低疗效甚至产生严重的毒副作用,但由于其临床数据有限以及缺乏有效的药效学监测方法,从而在临床治疗中存在着用药风险。本文通过查阅国内外相关文献对NVB体内药动学及毒副作用研究进展进行总结,充分了解NVB的药动学特点及影响因素、毒副作用的影响因素、药动学在给药方案调整中的应用现状,为其临床合理使用提供参考。Vinorelbine(NVB)is a semisynthetic vinca alkaloid and can play an anti-tumor role by inhibiting the synthesis of tubulin.Its oral preparation has been used in the treatment of a variety of tumors as its convenience and good clinical response.The blood concentration of NVB is closely related to its curative effect and toxicity.Small variations in blood concentration may reduce the curative effect and even produce serious toxicity.There are some risks in the clinical drug use due to limited clinical data and effective pharmacodynamic monitoring methods.By reviewing the relevant literature at home and abroad,this paper summarizes the research progress of in vivo pharmacokinetics and toxicity of NVB,fully understands the pharmacokinetic characteristics and influencing factors of NVB,the influencing factors of toxicity,and the application status of pharmacokinetics in the adjustment of administration scheme,so as to provide reference for its clinical rational use.

关 键 词：抗肿瘤药 长春瑞滨 药动学 疗效 毒副作用 药效学指标 

分 类 号：R969.1[医药卫生—药理学] R979.1[医药卫生—药学]