华中五味子藤茎中苯丙素类化学成分研究  

Phenylpropanoids from the stems of Schisandra sphenanthera

作　　者：杨洁 孙琛 郭东艳 刘银环 YANG Jie;SUN Chen;GUO Dong-yan;LIU Yin-huan(School of Pharmacy,Shaanxi University of Chinese Medicine,Shaanxi Key Laboratory of Traditional Chinese Medicine Foundation and New Drug Research,Xianyang Shaanxi 712046;Department of Pharmacy,Xianyang Central Hospital,Xianyang Shaanxi 712000)

机构地区：[1]陕西中医药大学药学院,陕西省中药基础与新药研究重点实验室,陕西咸阳712046 [2]咸阳市中心医院药剂科,陕西咸阳712000

出　　处：《中南药学》2022年第5期1044-1047,共4页Central South Pharmacy

基　　金：陕西省教育厅科学研究计划项目(No.17JK0205);陕西省中医药管理局中医药科研课题(No.ZCMS008).

摘　　要：目的研究华中五味子藤茎中的苯丙素类化学成分。方法采用硅胶柱色谱,葡聚糖凝胶LH-20柱色谱以及半制备高效液相色谱等方法分离化学成分,MS和NMR等数据鉴定化合物的结构。结果从五味子藤茎中共分离鉴定了9个化合物,分别为肉桂酸(1),3,4,5-三甲氧基肉桂酸(2),erythro-7-methoxyguaiacylglycerol(3),3-(4-hydroxy-3-methoxy-phenyl)propan-1,2-diol(4),3-羟基-1-(3-甲氧基-4-羟基-苯基)-丙基-1-酮(5),对羟基苯丙醇(6),3-甲氧基-4-羟基苯丙醇(7),1-(3-methoxy-4-hydroxy-phenyl)-propan-1,2-diol(8),C-veratroylglycol(9)。结论化合物1~6为首次从该植物中分离鉴定。Objective To determine the phenylpropanoids in the stems of Schisandra sphenanthera.Methods The chemical constituents were studied by chromatography on silica gel,Sephadex LH-20 and semi-preparative HPLC.The structures were elucidated on the basis of spectroscopic methods,including MS and NMR spectral techniques.Results Nine phenylpropanoids were obtained from the stems of Schisandra sphenanthera and identified as cinnamic acid(1),3,4,5-trimethoxy-cinnammic acid(2),erythro-7-methoxyguaiacylglycerol(3),3-(4-hydroxy-3-methoxy-phenyl)propan-1,2-diol(4),β-hydroxypropiovanillone(5),p-hydroxyl-benzyl-propanol(6),3-hydroxy-1-(4-hydroxy-phenyl)propan-1-one(7),1-(3-methoxy-4-hydroxy-phenyl)-propan-1,2-diol(8)and C-veratroylglycol(9).Conclusion Compounds 1-6 have been isolated from this plant for the first time.

关 键 词：华中五味子 化学成分 苯丙素类化合物 肉桂酸 

分 类 号：R284.1[医药卫生—中药学]