基于尿酸转运蛋白的中药治疗高尿酸血症的研究进展  

Research progress in traditional Chinese medicine treatment based on uric acid transporter for hyperuricemia

作　　者：张凤阳 邢志华[1,2] 申光焕 高原 韩维娜[3] 程美池 徐志远[1,2] ZHANG Feng-yang;XING Zhi-hua;SHEN Guang-huan;GAO Yuan;HAN Wei-na;CHENG Mei-chi;XU Zhi-yuan(School of Pharmacy,Harbin University of Commerce,Harbin 150076;Key Laboratory for Drug Research on Prevention and Treatment of Geriatric Diseases of Heilongjiang,Harbin 150076;School of Pharmacy,Harbin Medical University,Harbin 150081)

机构地区：[1]哈尔滨商业大学药学院,哈尔滨150076 [2]黑龙江省预防与治疗老年病药物研究重点实验室,哈尔滨150076 [3]哈尔滨医科大学药学院,哈尔滨150081

出　　处：《中南药学》2022年第5期1123-1128,共6页Central South Pharmacy

基　　金：黑龙江省自然科学基金面上项目(No.H2016001);黑龙江省留学回国人员择优资助项目(No.18930101);黑龙江省博士后科研启动基金(No.LBH-Q15111);哈尔滨商业大学研究生科研创新项目(No.YJSCX2020-684HSD)。

摘　　要：近年来,高尿酸血症及其引发的痛风引起了医药学界的高度重视。随着对高尿酸血症发病机制研究的不断深入,发现了一系列在体内尿酸转运中发挥重要作用的尿酸转运蛋白,这些蛋白按照功能分为尿酸分泌蛋白、尿酸重吸收蛋白和其他如骨架蛋白等,以尿酸转运蛋白为分子靶点开发具有作用机制明确的中药具有重要意义。因此,本文围绕尿酸转运蛋白,对中药治疗高尿酸血症及其机制的研究进展进行综述,为中药降尿酸研究提供参考。In recent years,hyperuricemia and the gout caused by it has attracted much attention.With the research on the pathogenesis of hyperuricemia,many uric acid transporter proteins have been discovered that play an important role in uric acid transportation in vivo.These proteins can be divided into reabsorption proteins,excretion proteins and skeletal proteins.It is important to develop traditional Chinese medicine(TCM)with clear mechanism of action using uric acid transporter as the molecular targets.Revolving around uric acid transporter,this paper reviewed the research progress in TCM treatment of hyperuricemia and its mechanism,and provides reference for reduction of uric acid by TCM.

关 键 词：中药 高尿酸血症 尿酸排泄 尿酸转运蛋白 

分 类 号：R282.71[医药卫生—中药学]