美托洛尔联合厄贝沙坦氢氯噻嗪治疗老年重症心力衰竭的疗效研究  

Study on the efficacy of metoprolol combined with irbesartan and hydrochlorothiazide in the treatment of senile patients with severe heart failure

作　　者：刘飞飞 王伟 LIU Fei-fei;WANG Wei(People’s Hospital of Guangrao County,Dongying 257300,China)

机构地区：[1]广饶县人民医院,257300

出　　处：《中国实用医药》2022年第9期1-3,共3页China Practical Medicine

摘　　要：目的探讨美托洛尔联合厄贝沙坦氢氯噻嗪治疗老年重症心力衰竭的临床效果。方法74例老年重症心力衰竭患者,按随机数字表法分为对照组和观察组,各37例。对照组应用美托洛尔治疗,观察组应用美托洛尔联合厄贝沙坦氢氯噻嗪治疗。对比两组患者临床疗效,治疗前后心功能指标[左室射血分数(LVEF)、左室收缩末期内径(LVESD)和左室舒张末期内径(LVEDD)]、B型脑钠肽(BNP)水平、6 min步行试验(6MWT),药物不良反应发生率。结果观察组治疗总有效率97.30%高于对照组的81.08%,差异有统计学意义(P<0.05)。治疗前,两组LVEF、LVESD、LVEDD对比,差异无统计学意义(P>0.05);治疗后,观察组LVEF(55.65±2.19)%高于对照组的(49.19±3.62)%,LVESD(24.35±2.95)mm、LVEDD(47.19±2.06)mm小于对照组的(28.19±3.16)、(55.13±3.19)mm,差异有统计学意义(P<0.05)。治疗前,两组6MWT、BNP水平对比,差异无统计学意义(P>0.05);治疗后,观察组6MWT长于对照组,BNP水平低于对照组,差异有统计学意义(P<0.05)。两组药物不良反应发生率对比,差异无统计学意义(P>0.05)。结论对老年重症心力衰竭患者应用美托洛尔联合厄贝沙坦氢氯噻嗪治疗可获得满意疗效,有助于改善患者心功能并迅速缓解病情,且用药安全性良好。Objective To discuss the clinical effect of metoprolol combined with irbesartan and hydrochlorothiazide in the treatment of senile patients with severe heart failure.Methods A total of 74 cases of senile patients with severe heart failure were randomly divided into control group and observation group,with 37 cases in each group.The control group was treated with metoprolol,and the observation group was treated with metoprolol combined with irbesartan and hydrochlorothiazide.Both groups were compared in terms of clinical efficacy,cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD)and left ventricular end-diastolic diameter(LVEDD)]and brain natriuretic peptide(BNP)and 6 min walking test(6MWT)before and after treatment,and the incidence of adverse drug reactions.Results The total effective rate 97.30%of the observation group was higher than 81.08%of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in LVEF,LVESD and LVEDD between the two groups(P>0.05).After treatment,the LVEF(55.65±2.19)%of the observation group was higher than(49.19±3.62)%of the control group,and the LVESD(24.35±2.95)mm and LVEDD(47.19±2.06)mm were less than(28.19±3.16)and(55.13±3.19)mm of the control group.All the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in 6MWT and BNP between the two groups(P>0.05).After treatment,the 6MWT in the observation group was longer than that in the control group,and the BNP in the observation group was lower than that in the control group.All the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse drug reactions between the two groups(P>0.05).Conclusion The combination of metoprolol and irbersartan and hydrochlorothiazide in the treatment of elderly patients with severe heart failure can achieve satisfactory eff

关 键 词：重症心力衰竭 美托洛尔 厄贝沙坦氢氯噻嗪 心功能 

分 类 号：R541.6[医药卫生—心血管疾病]