氧驱雾化吸入盐酸氨溴索治疗慢阻肺急性加重期患者的疗效  

Efficacy of oxygen-driven ambroxol hydrochloride aerosol inhalation on patients with acute exacerbation of chronic obstructive pulmonary disease

作　　者：张颢 ZHANG Hao(Shenyang Sixth People’s Hospital,Shenyang 110000,China)

机构地区：[1]沈阳市第六人民医院,110000

出　　处：《中国实用医药》2022年第9期119-122,共4页China Practical Medicine

摘　　要：目的探讨氧驱雾化吸入盐酸氨溴索治疗慢性阻塞性肺疾病(慢阻肺)急性加重期患者的疗效。方法78例慢阻肺急性加重期患者,根据治疗方法不同分为对照组和观察组,每组39例。对照组给予常规方案治疗,观察组在对照组基础上给予氧驱雾化吸入盐酸氨溴索治疗。比较两组治疗前后肺功能指标(峰流速、最大呼气中段流量)、炎症因子(肿瘤坏死因子-α、超敏C反应蛋白、白细胞介素-6)水平、治疗效果、生化检查指标恢复正常时间、咳嗽咳痰消失时间、不良反应发生情况。结果治疗后,观察组峰流速(2.13±0.32)L/s、最大呼气中段流量(1.64±0.24)L/s均大于对照组的(1.42±0.23)、(1.23±0.22)L/s,超敏C反应蛋白(7.56±1.21)mg/L、肿瘤坏死因子-α(1.45±0.21)ng/ml、白细胞介素-6(61.01±2.21)pg/ml均显著低于对照组的(9.13±1.56)mg/L、(2.24±0.28)ng/ml、(111.14±2.15)pg/ml,差异具有统计学意义(P<0.05)。观察组患者治疗总有效率为100.00%(39/39),高于对照组的82.05%(32/39),差异具有统计学意义(P<0.05)。观察组患者生化检查指标恢复正常时间、咳嗽咳痰消失时间分别为(8.56±1.15)、(6.64±1.21)d,均短于对照组的(9.26±1.24)、(11.54±2.44)d,差异具有统计学意义(P<0.05)。两组均未见严重不良反应。结论慢阻肺急性加重期患者采用盐酸氨溴索联合常规方案治疗可更好改善患者病情,可缩短治疗的时间,控制肺部炎症和改善肺功能,且安全性高,无严重副作用。Objective To discuss the efficacy of oxygen-driven ambroxol hydrochloride aerosol inhalation on patients with acute exacerbation of chronic obstructive pulmonary disease.Methods A total of 78 patients with acute exacerbation of chronic obstructive pulmonary disease were divided into control group and observation group according to different treatment methods,with 39 cases in each group.The control group was treated with conventional treatment,and the observation group was treated with oxygen-driven ambroxol hydrochloride aerosol inhalation on the basis of the control group.Both groups were compared in terms of levels of pulmonary function indexes(peak flow rate,maximum mid-expiratory flow),inflammatory factors(tumor necrosis factor-α,highsensitivity C-reactive protein,interleukin-6),therapeutic effect,recovery time of biochemical test indicators,disappearance time of cough and sputum,and the occurrence of adverse reactions.Results After treatment,the peak flow rate(2.13±0.32)L/s and the maximum mid-expiratory flow(1.64±0.24)L/s in the observation group were higher than(1.42±0.23)and(1.23±0.22)L/s in the control group;the high-sensitivity C-reactive protein(7.56±1.21)mg/L,tumor necrosis factor-α(1.45±0.21)ng/ml,and interleukin-6(61.01±2.21)pg/ml were significantly lower than(9.13±1.56)mg/L,(2.24±0.28)ng/ml,(111.14±2.15)pg/ml in the control group;all the differences were statistically significant(P<0.05).The total effective rate in the observation group was 100.00%(39/39),which were higher than 82.05%(32/39)in the control group,and the difference was statistically significant(P<0.05).The recovery time of biochemical test indicators and disappearance time of cough and sputum in the observation group were(8.56±1.15)and(6.64±1.21)d,which were shorter than(9.26±1.24)and(11.54±2.44)d in the control group,and the difference was statistically significant(P<0.05).No serious adverse reactions were observed in both groups.Conclusion Ambroxol hydrochloride combined with conventional treatment can better improv

关 键 词：氧驱雾化吸入 盐酸氨溴索 慢性阻塞性肺疾病急性加重期 疗效 

分 类 号：R563.9[医药卫生—呼吸系统]