孟鲁司特联合沙丁胺醇雾化吸入治疗小儿哮喘急性发作的临床效果  

Clinical effect of montelukast combined with salbutamol aerosol inhalation in the treatment of acute attack of asthma in children

作　　者：吴冰 WU Bing(Department of Pediatrics,Dongbei International Hospital,Shenyang 110000,China)

机构地区：[1]东北国际医院儿科,110000

出　　处：《中国实用医药》2022年第9期127-130,共4页China Practical Medicine

摘　　要：目的分析孟鲁司特联合沙丁胺醇雾化吸入治疗小儿哮喘急性发作的临床疗效。方法84例小儿哮喘急性发作患儿,以随机数字表法分为观察组与对照组,各42例。对照组采取沙丁胺醇雾化吸入治疗方案,观察组采取沙丁胺醇雾化吸入联合孟鲁司特治疗方案。比较两组肺功能指标、肺部炎症指标、哮喘症状积分、焦虑自评量表(SAS)评分、临床疗效、不良反应发生情况。结果治疗后,观察组用力肺活量(FVC)(3.74±1.34)L、第1秒用力呼气容积(FEV1)(3.12±0.31)L,均高于对照组的(2.42±1.11)L、(2.23±0.24)L,差异有统计学意义(P<0.05)。治疗后,观察组肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)均低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组日间哮喘症状积分(0.51±0.11)分、夜间哮喘症状积分(0.56±0.12)分、SAS评分(31.19±2.42)分,均低于对照组的(1.13±0.26)、(1.02±0.23)、(42.14±2.34)分,差异有统计学意义(P<0.05)。观察组临床总有效率92.86%(39/42)高于对照组的76.19%(32/42),差异有统计学意义(P<0.05)。两组均未出现不良反应。结论沙丁胺醇雾化吸入联合孟鲁司特治疗小儿哮喘急性发作的临床疗效确切,可有效控制肺部炎症、哮喘症状积分和改善肺功能,安全性高,具有临床推广价值。Objective To analyze the clinical efficacy of montelukast combined with salbutamol aerosol inhalation in the treatment of acute attack of asthma in children.Methods A total of 84 children with acute attack of asthma were divided into observation group and control group by random numerical table,with 42 cases in each group.The control group received salbutamol aerosol inhalation therapy,and the observation group received salbutamol aerosol inhalation combined with montelukast therapy.The pulmonary function indexes,pulmonary inflammation indexes,asthma symptom scores,self-rating anxiety scale(SAS)score,clinical efficacy,and occurrence of adverse reactions were compared between the two groups.Results After treatment,the forced vital capacity(FVC)in the observation group was(3.74±1.34)L,and the forced expiratory volume in the 1st second(FEV1)was(3.12±0.31)L,which were higher than(2.42±1.11)and(2.23±0.24)L in the control group,and the difference was statistically significant(P<0.05).After treatment,the tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6)in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the daytime asthma symptom score(0.51±0.11)points,nighttime asthma symptom score(0.56±0.12)points,and SAS score(31.19±2.42)points of the observation group were lower than(1.13±0.26),(1.02±0.23),and(42.14±2.34)points of the control group,and the differences were statistically significant(P<0.05).The total clinical effective rate 92.86%(39/42)of the observation group was higher than 76.19%(32/42)of the control group,and the difference was statistically significant(P<0.05).No adverse reactions were observed in both groups.Conclusion Salbutamol aerosol inhalation combined with montelukast is effective in the treatment of acute attack of asthma in children,which can control lung inflammation,asthma symptom score and improve lung function,with high safety and popularization value.

关 键 词：小儿哮喘急性发作 沙丁胺醇 雾化吸入 孟鲁司特 

分 类 号：R725.6[医药卫生—儿科]