经鼻高流量氧疗对AECOPD合并呼吸衰竭患者的影响  

Effect of Transnasal High Flow Oxygen Therapy on Patients with AECOPD Complicated with Respiratory Failure

作　　者：林玉霞 尚嘉伟[1] LIN Yuxia;SHANG Jiawei(Fujian Hospital of Shanghai Sixth People’s Hospital,Quanzhou 362600,China;不详)

机构地区：[1]上海市第六人民医院福建医院,福建泉州362600

出　　处：《中外医学研究》2022年第13期26-29,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：泉州市科技计划项目(2019N006S)。

摘　　要：目的:探讨经鼻高流量氧疗(HFNC)对AECOPD合并呼吸衰竭患者的影响。方法:按照给氧方式将上海市第六人民医院福建医院2019年7月-2021年2月140例AECOPD合并Ⅱ型呼吸衰竭患者分组,HFNC组70例给予HFNC治疗,无创呼吸机辅助通气(NIPPV)组70例给予NIPPV治疗。对比两组临床疗效、呼吸功能[圣乔治呼吸问卷(SGRQ)]评分变化、总住院时间、通气治疗时间,以及TNF-α、IL-6、IL-8水平。结果:HFNC组的临床总有效率高于NIPPV组(P<0.05);与治疗前相比,治疗后两组患者SGRQ评分均降低,且HFNC组低于NIPPV组(P<0.05);治疗后HFNC组患者总住院时间、通气治疗时间均短于NIPPV组,但两组间相比差异无统计学意义(P>0.05);与治疗前相比,治疗后两组患者TNF-α、IL-6、IL-8水平均降低,且HFNC组低于NIPPV组(P<0.05)。结论:HFNC可提高AECOPD合并呼吸衰竭患者的临床疗效,改善呼吸功能,减轻炎症反应。Objective:To investigate the effect of transnasal high flow oxygen therapy(HFNC)on patients with AECOPD complicated with respiratory failure.Method:A total of 140 patients with AECOPD complicated with typeⅡrespiratory failure in Fujian Hospital of Shanghai Sixth People’s Hospital from July 2019 to February 2021 were divided into two groups according to the mode of oxygen supply.70 patients in the HFNC group were treated with HFNC and 70 patients in the NIPPV group were treated with NIPPV.The clinical efficacy,respiratory function[St.George’s respiratory questionnaire(SGRQ)]scores,total hospital stay,ventilation treatment time and TNF-α,IL-6,IL-8 levels were compared between the two groups.Result:The total effective rate of HFNC group was higher than that of NIPPV group(P<0.05).Compared with before treatment,the SGRQ score of the two groups after treatment decreased,and that of HFNC group was lower than that of NIPPV group(P<0.05).After treatment,the total hospital stay and ventilation treatment time in HFNC group were shorter than those in NIPPV group,but there were no significant differences between the two groups(P>0.05).Compared with before treatment,levels of TNF-α,IL-6 and IL-8 in the two groups after treatment decreased,which in HFNC group were lower than those in NIPPV group(P<0.05).Conclusion:Transnasal high flow oxygen therapy can improve the clinical efficacy,improve respiratory function and reduce inflammatory reaction in patients with AECOPD complicated with respiratory failure.

关 键 词：Ⅱ型呼吸衰竭 无创呼吸机辅助通气 经鼻高流量氧疗 生理指标 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统] R563.8[医药卫生—内科学]