肾纤维化手术动物模型构建及相关机制研究进展  

Animal model construction and related mechanism of renal fibrosis with surgery

作　　者：刘洋 张瑞红 只素娟 刘兰兰 刘旭玥 冯晓宁 张晓丽 Liu Yang;Zhang Ruihong;Zhi Sujuan;Liu Lanlan;Liu Xuyue;Feng Xiaoning;Zhang Xiaoli(Department of Human Anatomy,Histology and Embryology,School of Basic Medical Sciences,Cheeloo College of Medicine,Shandong University,Jinan 250012,China)

机构地区：[1]山东大学齐鲁医学院基础医学院人体解剖学与组织学胚胎学教研室,济南250012

出　　处：《解剖学杂志》2022年第2期157-160,共4页Chinese Journal of Anatomy

基　　金：国家自然科学基金(81672861、81270661);山东省自然科学基金(ZR2014HM017);山东省科技发展计划(2017GSF218029)

摘　　要：慢性肾疾病发展到一定阶段可引起肾纤维化。肾纤维化可由多种因素诱导产生,包括肾受到严重创伤和感染,肾血液循环阻塞或者免疫反应等。各种因素引起肾组织受损后,大量胶原纤维在间质沉积,瘢痕形成,导致肾结构和功能发生改变,从而引起肾纤维化。迄今关于肾纤维化的发生机制尚不完全明确,而理想的肾纤维化模型对于肾纤维化的机制研究具有重要意义。目前很多关于肾纤维化的研究是通过手术的方式建立肾纤维化的动物模型。因此本文主要总结了近年来关于肾纤维化手术模型的构建方法及肾纤维化的发病机制。The progression of various chronic kidney disease to a certain stage leads to renal fibrosis.Renal fibrosis can be stimulated by a variety of factors,including kidney trauma,infection,blood circulation blockage or immune response,etc.After renal tissue damage caused by these factors,a large number of collagen fibers deposited in the stroma to form fibrous scars,which resulted in changes of renal structure and function and further led to renal fibrosis.So far,the mechanism of renal fibrosis remains not fully understood.The establishment of an ideal animal model is of great significance for the study of the mechanism of renal fibrosis.Numerous literatures reported the establishment of animal models of renal fibrosis through surgery.Therefore,this article focused on the methods of establishment of animal model of renal fibrosis by surgery and the pathogenesis of renal fibrosis in recent years.

关 键 词：肾纤维化 手术 动物模型 发病机制 

分 类 号：R699.2[医药卫生—泌尿科学] R-332[医药卫生—外科学]