急性缺血性脑卒中的靶点治疗研究进展  

Research progress in target therapy for acute ischemic stroke

作　　者：黄丽丽 谢静文 HUANG Li-li;XIE Jing-wen(Department of Pharmacy,Lihuili Hospital Affiliated to Ningbo University,Ningbo 315040,China;Biochemistry Engineering Department,Chongqing Industry&Trade Polytechnic,Chongqing 408000,China)

机构地区：[1]宁波大学附属李惠利医院药剂科,浙江宁波315000 [2]重庆工贸职业技术学院健康学院,重庆408000

出　　处：《实用药物与临床》2022年第5期476-480,共5页Practical Pharmacy and Clinical Remedies

基　　金：国家自然科学基金(82003755);宁波市医学科技计划项目(2019Y07)。

摘　　要：急性缺血性脑卒中(AIS)是最常见的脑卒中类型,具有高发病率、高致残率和高致死率等特点。目前,临床治疗主要有静脉溶栓和取栓术等,但其疗效均不理想。本文对AIS的应激级联反应中潜在的治疗靶点进行总结,以期为AIS提出更具针对性的治疗思路或策略。Acute ischemic stroke(AIS)is the most common type of stroke,characterized by high incidence,high disability and high mortality.At present,the clinical treatment mainly includes intravenous thrombolysis and thrombectomy,but the curative effect is unsatisfactory.This article summarizes the potential therapeutic targets in the stress cascade of AIS,in order to provide more targeted treatment ideas or strategies for AIS.

关 键 词：急性缺血性脑卒中 靶点 脑缺血再灌注损伤 缺血半影区 

分 类 号：R743.3[医药卫生—神经病学与精神病学]