嗜酸性粒细胞凋亡在变应性鼻炎发病机制中的作用研究  

The role of eosinophil apoptosis in the pathogenesis of allergic rhinitis

作　　者：鲍有为 朱新华[1] BAO Youwei;ZHU Xinhua(Department of Otorhinolaryngology,The Second Affiliated Hospital of Nanchang University,Nanchang,Jiangxi,330000,China)

机构地区：[1]南昌大学第二附属医院耳鼻咽喉头颈外科,江西南昌330000

出　　处：《中国中西医结合耳鼻咽喉科杂志》2022年第2期81-87,共7页Chinese Journal of Otorhinolaryngology in Integrative Medicine

基　　金：国家自然科学基金项目(NO:81860184);国家自然科学基金项目(NO:81560171);江西省自然科学基金资助项目(NO:S2020ZRMSB1010)。

摘　　要：嗜酸性粒细胞(EOS)在哮喘和其他变态反应性疾病的发病过程中是重要的效应细胞。在变应性炎症过程中,对凋亡细胞的凋亡和胞吐作用的药理作用的研究,为炎症性气道疾病的治疗提供了新的见解,尤其是以嗜酸性粒细胞为主的气道炎症。这两种方法可用于治疗干预,允许成功操控炎症解决,并减少与现有治疗相关的不良反应。因此,通过控制EOS凋亡来调控变应性炎症,目前并且未来可能是过敏性疾病的主要治疗关注点。Eosinophils are important effector cells in the pathogenesis of asthma and other allergic diseases.In the process of allergic inflammation,the research on the pharmacological effects of apoptosis and exocytosis of apoptotic cells provides new insights for the treatment of inflammatory airway diseases,especially airway inflammation mainly composed of eosinophils.These two approaches can be used for therapeutic interventions that allow successful manipulation of inflammation resolution and reduce adverse reactions associated with existing treatments.Therefore,controlling eosinophil apoptosis to regulate allergic inflammation is the main therapeutic target of allergic diseases at present and in the future.

关 键 词：嗜酸性粒细胞 变应性鼻炎 细胞凋亡 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]