观察新癀片含化对慢性扁桃体炎(隐窝型)的治疗作用  

The treatment of Xinhuang tablets for chronic tonsillitis(cryptic type)

作　　者：蔺林 戴飞 任国强 魏瑾瑾 陈峥 汤欣玥 LIN Lin;DAI Fei;REN Guoqiang;WEI Jinjin;CHEN Zheng;TANG Xinyue(Department of Otorhinolaryngology-Head and Neck Surgery,Huashan Hospital North of Fudan University,Shanghai,201907,China)

机构地区：[1]复旦大学附属华山医院北院耳鼻咽喉头颈外科,201907 [2]复旦大学附属华山医院北院病理科

出　　处：《中国中西医结合耳鼻咽喉科杂志》2022年第2期108-111,126,共5页Chinese Journal of Otorhinolaryngology in Integrative Medicine

摘　　要：目的探讨新癀片含化对慢性扁桃体炎(隐窝型)的治疗作用,寻找治疗慢性隐窝型扁桃体炎(chronic cryptic tonsillitis,CCT)的合适方法。方法研究对象24例,为确诊为CCT的患者,干预手段为新癀片含化,每日4次,每次1片,干预时间为4周,在治疗前和治疗后分别取CTT患者扁桃体窝内的排出物,以显微镜涂片检测其中脱落细胞数,并用酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)检测其中炎症介质白介素(interleukin,IL)-1β、IL-6、IL-8和肿瘤坏死因子(tumor necrosis factor,TNF)-α的浓度。结果24例患者完成了该项研究。新癀片含化治疗第4周末与治疗前相比较,扁桃体窝内的排出物中脱落细胞数经涂片镜检发现其显著减少,而且排出物中炎症介质IL-1β、IL-6、IL-8和TNF-α的浓度经ELISA检测也发现其明显降低,治疗前后之间的差异具有统计学意义。结论新癀片含化对CTT患者有明确的治疗作用,适合于治疗该病。Objective To investigate the treatment of Xinhuang tablets for chronic tonsillitis(cryptic type)and to confirm the appropriate medication for chronic cryptic tonsillitis(CTT).Methods The participated twenty-four subjects were diagnosed as CTT patients in this study.The interventive measure included dissolving Xinhuang tablet in their mouth,4 times per day,1 tablet per time.And the period of the treatment was 4 weeks.Discharges from the crypts of tonsils were obtained from CTT patients before and after this treatment.The numbers of exfoliated cells were counted through the smear technique microscopically.And the concentrations of inflammatory mediators interleukin(IL)-1β,IL-6,IL-8 and tumor necrosis factor(TNF)-αwere examined using enzyme-linked immunosorbent assay(ELISA).Results Twenty-four patients completed the study.The numbers of exfoliated cells from discharges of tonsil crypt were reduced significantly with the smear and microscopic assessment after 4-week treatment of Xinhuang tablets compared to those before the treatment.And the concentrations of inflammatory mediators IL-1β,IL-6,IL-8 and TNF-αin the discharges were also decreased through ELISA when compared with those before Xinhuang tablets therapy.There were statistical differences before and after this intervention.Conclusion Xinhuang Tablet contains a clear therapeutic effect on CTT patients and is suitable for the treatment of the disease.

关 键 词：慢性扁桃体炎 隐窝 新癀片 治疗 炎症介质 

分 类 号：R276.1[医药卫生—中医五官科学]