小青龙汤加味治疗咳嗽变异性哮喘(寒咳型)患儿的临床疗效分析  

Clinical Efficacy Analysis of Xiaoqinglong Decoction in the Treatment of Children with Cough Variant Asthma(Cold Cough Type)

作　　者：杨宏强 YANG Hongqiang(Department of Traditional Chinese Medicine and Pediatrics,the Second People's Hospital of Ningxian County,Qingyang,Gansu Province,745201 China)

机构地区：[1]甘肃省庆阳市宁县第二人民医院中医儿科,甘肃庆阳745201

出　　处：《系统医学》2022年第7期144-148,共5页Systems Medicine

摘　　要：目的探讨在治疗咳嗽变异性哮喘(寒咳型)患儿时采用小青龙汤加味的临床效果。方法选取2020年2月—2021年2月医院收治的患有咳嗽变异性哮喘(寒咳型)患儿共有80例。采用随机抽签法将患儿平均分成对照组和研究组,每组40例,对照组采用常规西药治疗,研究组采用小青龙汤加味治疗,对比患儿肺功能指标、临床症状积分、治疗有效率、炎症因子指标及复发率情况。结果研究组患儿最大呼气中段平均流速(MMEF)(1.28±0.22)L/s、第一秒用力呼吸量(FEV1)(2.39±0.28)L及第一秒用力呼气量占用力肺活量的比值(FEV1/FVC)(59.63±3.27)%指标均显著提高且高于对照组,差异有统计学意义(t=3.600、4.440、7.662,P<0.05);研究组患儿咳嗽(1.48±0.17)分、喘息(1.58±0.19)分、咯痰(1.53±0.31)分降低幅度较对照组患儿低,差异有统计学意义(t=24.579、24.712、9.521,P<0.05);研究组患儿总体治疗有效率95.00%较对照组患儿77.50%要高,差异有统计学意义(χ^(2)=5.164,P<0.05);研究组患儿白细胞介素-6(IL-6)(6.22±2.24)ng/L、白细胞介素-8I(L-8)(223.45±24.53)ng/L、肿瘤坏死因子(TNF-α)(13.54±2.35)ng/L水平降低显著且低于对照组患儿,差异有统计学意义(t=4.213、11.486、10.044,P<0.05);研究组患儿复发率5.00%显著低于对照组20.00%,差异有统计学意义(χ^(2)=4.114,P<0.05)。结论采用小青龙汤加味治疗寒咳型咳嗽变异性哮喘患儿具有显著的疗效,可降低炎性指标,改善临床症状并提高肺功能,减少复发率,建议推广应用。Objective To investigate the clinical effect of Xiaoqinglong Decoction in the treatment of children with cough variant asthma(cold cough type).Methods A total of 80 children with cough variant asthma(cold cough type)admitted to the hospital from February 2020 to February 2021 were selected.The children were equally divided into the control group and the study group by random drawing,and 40 children were included in each group.The control group was treated with conventional western medicine,and the study group was treated with Xiaoqinglong Decoction.The pulmonary function indexes,clinical symptom scores,treatment effective rate,inflammatory factor indexes and recurrence rate of the children were compared.Results The indexes of MMEF(1.28±0.22)L/s,FEV1(2.39±0.28)L and FEV1/FVC(59.63±3.27)%of the children in the study group were significantly increased and higher than those in the control group,the difference was statistically significant(t=3.600,4.440,7.662,P<0.05);compared with the children in the control group,the children in the study group had a lower reduction in the scores of cough(1.48±0.17)points,wheezing(1.58±0.19)points and expectoration(1.53±0.31)points,the difference was statistically significant(t=24.579, 24.712, 9.521, P<0.05);the overall treatment effective rate of the children in the study group was 95.00% higher than that of the children in the control group 77.50%, the difference was statistically significant(χ^(2)=5.164, P<0.05);the levels of IL-6 (6.22±2.24) ng/L, IL-8 (223.45±24.53) ng/L and TNF-α (13.54±2.35) ng/L in the study group were significantly lower than those in the control group, the difference was statistically significant(t=4.213, 11.486, 10.044, P<0.05);the recurrence rate of the children in the study group was 5.00%, which was significantly lower than that in the control group, which was 20.00%, the difference was statistically significant(χ^(2)=4.114, P<0.05). Conclusion Modified Xiaoqinglong Decoction has a significant curative effect in the treatment of children wit

关 键 词：咳嗽变异性哮喘 患儿 寒咳型 小青龙汤加味治疗 炎症因子 肺功能 

分 类 号：R72[医药卫生—儿科]